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Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models

BACKGROUND: Fibroblast growth factor receptor (FGFR) signalling has been implicated in pancreas carcinogenesis. We investigated the effect of FGFR inhibition in pancreatic cancer in complementary cancer models derived from cell lines and patient-derived primary tumour explants. METHODS: The effects...

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Detalles Bibliográficos
Autores principales:	Zhang, H, Hylander, B L, LeVea, C, Repasky, E A, Straubinger, R M, Adjei, A A, Ma, W W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899776/ https://www.ncbi.nlm.nih.gov/pubmed/24327018 http://dx.doi.org/10.1038/bjc.2013.754

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