Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

Neuropilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF) A and is essential for cardiovascular development. Biochemical evidence supports a model for NRP1 function in which VEGF binding induces complex formation between NRP1 and VEGFR2 to enhance endoth...

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Detalles Bibliográficos
Autores principales: Fantin, Alessandro, Herzog, Birger, Mahmoud, Marwa, Yamaji, Maiko, Plein, Alice, Denti, Laura, Ruhrberg, Christiana, Zachary, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Company of Biologists 2014
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899814/
https://www.ncbi.nlm.nih.gov/pubmed/24401374
http://dx.doi.org/10.1242/dev.103028

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