Altered Ca(2+) Homeostasis and Endoplasmic Reticulum Stress in Myotonic Dystrophy Type 1 Muscle Cells

The pathogenesis of Myotonic Dystrophy type 1 (DM1) is linked to unstable CTG repeats in the DMPK gene which induce the mis-splicing to fetal/neonatal isoforms of many transcripts, including those involved in cellular Ca(2+) homeostasis. Here we monitored the splicing of three genes encoding for Ca(...

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Detalles Bibliográficos
Autores principales: Botta, Annalisa, Malena, Adriana, Loro, Emanuele, Del Moro, Giulia, Suman, Matteo, Pantic, Boris, Szabadkai, Gyorgy, Vergani, Lodovica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899969/
https://www.ncbi.nlm.nih.gov/pubmed/24705164
http://dx.doi.org/10.3390/genes4020275

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