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Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters

BACKGROUND: A number of preanalytical activities strongly influence sample quality, especially those related to sample collection. Since blood drawing through intravenous catheters is reported as a potential source of erythrocyte injury, we performed a critical review and meta-analysis about the ris...

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Autores principales: Lippi, Giuseppe, Cervellin, Gianfranco, Mattiuzzi, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Society of Medical Biochemistry and Laboratory Medicine 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900066/
https://www.ncbi.nlm.nih.gov/pubmed/23894864
http://dx.doi.org/10.11613/BM.2013.022
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author Lippi, Giuseppe
Cervellin, Gianfranco
Mattiuzzi, Camilla
author_facet Lippi, Giuseppe
Cervellin, Gianfranco
Mattiuzzi, Camilla
author_sort Lippi, Giuseppe
collection PubMed
description BACKGROUND: A number of preanalytical activities strongly influence sample quality, especially those related to sample collection. Since blood drawing through intravenous catheters is reported as a potential source of erythrocyte injury, we performed a critical review and meta-analysis about the risk of catheter-related hemolysis. MATERIALS AND METHODS: We performed a systematic search on PubMed, Web of Science and Scopus to estimate the risk of spurious hemolysis in blood samples collected from intravenous catheters. A meta-analysis with calculation of Odds ratio (OR) and Relative risk (RR) along with 95% Confidence interval (95% CI) was carried out using random effect mode. RESULTS: Fifteen articles including 17 studies were finally selected. The total number of patients was 14,796 in 13 studies assessing catheter and evacuated tubes versus straight needle and evacuated tubes, and 1251 in 4 studies assessing catheter and evacuated tubes versus catheter and manual aspiration. A significant risk of hemolysis was found in studies assessing catheter and evacuated tubes versus straight needle and evacuated tubes (random effect OR 3.4; 95% CI = 2.9–3.9 and random effect RR 1.07; 95% CI = 1.06–1.08), as well as in studies assessing catheter and evacuated tubes versus catheter and manual aspiration of blood (OR 3.7; 95% CI = 2.7–5.1 and RR 1.32; 95% CI = 1.24–1.40). CONCLUSIONS: Sample collection through intravenous catheters is associated with significant higher risk of spurious hemolysis as compared with standard blood drawn by straight needle, and this risk is further amplified when intravenous catheter are associated with primary evacuated blood tubes as compared with manual aspiration.
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spelling pubmed-39000662014-01-23 Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters Lippi, Giuseppe Cervellin, Gianfranco Mattiuzzi, Camilla Biochem Med (Zagreb) Original Papers BACKGROUND: A number of preanalytical activities strongly influence sample quality, especially those related to sample collection. Since blood drawing through intravenous catheters is reported as a potential source of erythrocyte injury, we performed a critical review and meta-analysis about the risk of catheter-related hemolysis. MATERIALS AND METHODS: We performed a systematic search on PubMed, Web of Science and Scopus to estimate the risk of spurious hemolysis in blood samples collected from intravenous catheters. A meta-analysis with calculation of Odds ratio (OR) and Relative risk (RR) along with 95% Confidence interval (95% CI) was carried out using random effect mode. RESULTS: Fifteen articles including 17 studies were finally selected. The total number of patients was 14,796 in 13 studies assessing catheter and evacuated tubes versus straight needle and evacuated tubes, and 1251 in 4 studies assessing catheter and evacuated tubes versus catheter and manual aspiration. A significant risk of hemolysis was found in studies assessing catheter and evacuated tubes versus straight needle and evacuated tubes (random effect OR 3.4; 95% CI = 2.9–3.9 and random effect RR 1.07; 95% CI = 1.06–1.08), as well as in studies assessing catheter and evacuated tubes versus catheter and manual aspiration of blood (OR 3.7; 95% CI = 2.7–5.1 and RR 1.32; 95% CI = 1.24–1.40). CONCLUSIONS: Sample collection through intravenous catheters is associated with significant higher risk of spurious hemolysis as compared with standard blood drawn by straight needle, and this risk is further amplified when intravenous catheter are associated with primary evacuated blood tubes as compared with manual aspiration. Croatian Society of Medical Biochemistry and Laboratory Medicine 2013-06-15 /pmc/articles/PMC3900066/ /pubmed/23894864 http://dx.doi.org/10.11613/BM.2013.022 Text en ©Copyright by Croatian Society of Medical Biochemistry and Laboratory Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
Lippi, Giuseppe
Cervellin, Gianfranco
Mattiuzzi, Camilla
Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters
title Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters
title_full Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters
title_fullStr Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters
title_full_unstemmed Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters
title_short Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters
title_sort critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900066/
https://www.ncbi.nlm.nih.gov/pubmed/23894864
http://dx.doi.org/10.11613/BM.2013.022
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