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Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma

BACKGROUND: Melphalan resistance has been considered one of the major obstacles to improve outcomes in multiple myeloma (MM) therapy; unfortunately, the mechanistic details of this resistance remain unclear. Melphalan is a highly effective alkylating agent which causes many types of DNA lesions, inc...

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Detalles Bibliográficos
Autores principales:	Xie, Jiayin, Zhang, Liang, Li, Mengxia, Du, Jia, Zhou, Liwei, Yang, Senlin, Zeng, Linli, Li, Zengpeng, Wang, Ge, Wang, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900260/ https://www.ncbi.nlm.nih.gov/pubmed/24400589 http://dx.doi.org/10.1186/1471-2407-14-11

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