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Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid

BACKGROUND: Peeling is a procedure which aims to accelerate the process of skin exfoliation. OBJECTIVES: Development of formulations containing lactic acid at 85% or glycolic acid at 70% and the evaluation of these formulations on clinical efficacy in reduction of fine wrinkles. METHODS: Preliminary...

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Autores principales: Prestes, Paula Souza, de Oliveira, Márcia Motta Maia, Leonardi, Gislaine Ricci
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900339/
https://www.ncbi.nlm.nih.gov/pubmed/24474097
http://dx.doi.org/10.1590/abd1806-4841.20131888
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author Prestes, Paula Souza
de Oliveira, Márcia Motta Maia
Leonardi, Gislaine Ricci
author_facet Prestes, Paula Souza
de Oliveira, Márcia Motta Maia
Leonardi, Gislaine Ricci
author_sort Prestes, Paula Souza
collection PubMed
description BACKGROUND: Peeling is a procedure which aims to accelerate the process of skin exfoliation. OBJECTIVES: Development of formulations containing lactic acid at 85% or glycolic acid at 70% and the evaluation of these formulations on clinical efficacy in reduction of fine wrinkles. METHODS: Preliminary stability tests were carried out and an in vivo study was performed with three groups with 9 representatives each. One was the control group, which used only sunscreen; another one used lactic acid+sunscreen, and the last group used acid glycolic+sunscreen. Clinical efficacy was assessed with a CCD color microscope, through the digitization of images before and after treatment. The applications were carried out by a dermatologist, once a mont h every 30 days, during 3 months. The area with wrinkles was calculated by planimetry point counting, in accordance with Mandarin-de-Lacerda. RESULTS: The formulations were stable in the visual and Ph evaluation. There was no improvement in the control group; for lactic acid, there was significant improvement after the second peeling application on the outer lateral area of the right eye and after the third application on the outer lateral area of the left eye. For the glycolic acid group, there was significant improvement in the outer lateral area of the left eye after the first application, and of the right eye region, after three applications. The formulations used must be kept under refrigeration and should be manipulated every 30 days. CONCLUSIONS: Both peelings were effective in reducing fine wrinkles of the outer lateral eye area after three applications (p≤0.05%). It was observed that peeling efficacy in the external-lateral region of one eye might be different compared with that in skin of the external-lateral region of the other eye, relative to the speed of skin improvement.
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spelling pubmed-39003392014-01-29 Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid Prestes, Paula Souza de Oliveira, Márcia Motta Maia Leonardi, Gislaine Ricci An Bras Dermatol Investigation BACKGROUND: Peeling is a procedure which aims to accelerate the process of skin exfoliation. OBJECTIVES: Development of formulations containing lactic acid at 85% or glycolic acid at 70% and the evaluation of these formulations on clinical efficacy in reduction of fine wrinkles. METHODS: Preliminary stability tests were carried out and an in vivo study was performed with three groups with 9 representatives each. One was the control group, which used only sunscreen; another one used lactic acid+sunscreen, and the last group used acid glycolic+sunscreen. Clinical efficacy was assessed with a CCD color microscope, through the digitization of images before and after treatment. The applications were carried out by a dermatologist, once a mont h every 30 days, during 3 months. The area with wrinkles was calculated by planimetry point counting, in accordance with Mandarin-de-Lacerda. RESULTS: The formulations were stable in the visual and Ph evaluation. There was no improvement in the control group; for lactic acid, there was significant improvement after the second peeling application on the outer lateral area of the right eye and after the third application on the outer lateral area of the left eye. For the glycolic acid group, there was significant improvement in the outer lateral area of the left eye after the first application, and of the right eye region, after three applications. The formulations used must be kept under refrigeration and should be manipulated every 30 days. CONCLUSIONS: Both peelings were effective in reducing fine wrinkles of the outer lateral eye area after three applications (p≤0.05%). It was observed that peeling efficacy in the external-lateral region of one eye might be different compared with that in skin of the external-lateral region of the other eye, relative to the speed of skin improvement. Sociedade Brasileira de Dermatologia 2013 /pmc/articles/PMC3900339/ /pubmed/24474097 http://dx.doi.org/10.1590/abd1806-4841.20131888 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Investigation
Prestes, Paula Souza
de Oliveira, Márcia Motta Maia
Leonardi, Gislaine Ricci
Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid
title Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid
title_full Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid
title_fullStr Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid
title_full_unstemmed Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid
title_short Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid
title_sort randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid
topic Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900339/
https://www.ncbi.nlm.nih.gov/pubmed/24474097
http://dx.doi.org/10.1590/abd1806-4841.20131888
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