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Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology
Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most patients with hypo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900347/ https://www.ncbi.nlm.nih.gov/pubmed/24474105 http://dx.doi.org/10.1590/abd1806-4841.20132336 |
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author | Furlan, Fabricio Cecanho Sanches, José Antonio |
author_facet | Furlan, Fabricio Cecanho Sanches, José Antonio |
author_sort | Furlan, Fabricio Cecanho |
collection | PubMed |
description | Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most patients with hypopigmented mycosis fungoides are younger than patients typically diagnosed with classical mycosis fungoides. In addition to typical dark-skinned individuals impairment, hypopigmented mycosis fungoides has also been described in Asian patients. The prognosis for hypopigmented mycosis fungoides is much better than for classical mycosis fungoides: hypopigmented mycosis fungoides is diagnosed when there are only patches of affected skin, and lesions usually will not progress beyond terminal stages, although they can persist for many years. Diagnosis should involve clinicopathologic correlation: skin biopsy analysis often reveals intense epidermotropism, characterized by haloed, large, and atypical CD8+ lymphocytes with convoluted nuclei, in contrast to mild to moderate dermal lymphocytic infiltrate. These CD8+ cells, which participate in T helper 1-mediated immune responses, prevent evolution to mycosis fungoides plaques and tumors and could be considered the main cause of the inhibition of melanogenesis. Therefore, hypopigmentation could be considered a marker of good prognosis for mycosis fungoides. |
format | Online Article Text |
id | pubmed-3900347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-39003472014-01-29 Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology Furlan, Fabricio Cecanho Sanches, José Antonio An Bras Dermatol Review Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most patients with hypopigmented mycosis fungoides are younger than patients typically diagnosed with classical mycosis fungoides. In addition to typical dark-skinned individuals impairment, hypopigmented mycosis fungoides has also been described in Asian patients. The prognosis for hypopigmented mycosis fungoides is much better than for classical mycosis fungoides: hypopigmented mycosis fungoides is diagnosed when there are only patches of affected skin, and lesions usually will not progress beyond terminal stages, although they can persist for many years. Diagnosis should involve clinicopathologic correlation: skin biopsy analysis often reveals intense epidermotropism, characterized by haloed, large, and atypical CD8+ lymphocytes with convoluted nuclei, in contrast to mild to moderate dermal lymphocytic infiltrate. These CD8+ cells, which participate in T helper 1-mediated immune responses, prevent evolution to mycosis fungoides plaques and tumors and could be considered the main cause of the inhibition of melanogenesis. Therefore, hypopigmentation could be considered a marker of good prognosis for mycosis fungoides. Sociedade Brasileira de Dermatologia 2013 /pmc/articles/PMC3900347/ /pubmed/24474105 http://dx.doi.org/10.1590/abd1806-4841.20132336 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Furlan, Fabricio Cecanho Sanches, José Antonio Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology |
title | Hypopigmented mycosis fungoides: a review of its clinical features and
pathophysiology
|
title_full | Hypopigmented mycosis fungoides: a review of its clinical features and
pathophysiology
|
title_fullStr | Hypopigmented mycosis fungoides: a review of its clinical features and
pathophysiology
|
title_full_unstemmed | Hypopigmented mycosis fungoides: a review of its clinical features and
pathophysiology
|
title_short | Hypopigmented mycosis fungoides: a review of its clinical features and
pathophysiology
|
title_sort | hypopigmented mycosis fungoides: a review of its clinical features and
pathophysiology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900347/ https://www.ncbi.nlm.nih.gov/pubmed/24474105 http://dx.doi.org/10.1590/abd1806-4841.20132336 |
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