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Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology

Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most patients with hypo...

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Autores principales: Furlan, Fabricio Cecanho, Sanches, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900347/
https://www.ncbi.nlm.nih.gov/pubmed/24474105
http://dx.doi.org/10.1590/abd1806-4841.20132336
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author Furlan, Fabricio Cecanho
Sanches, José Antonio
author_facet Furlan, Fabricio Cecanho
Sanches, José Antonio
author_sort Furlan, Fabricio Cecanho
collection PubMed
description Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most patients with hypopigmented mycosis fungoides are younger than patients typically diagnosed with classical mycosis fungoides. In addition to typical dark-skinned individuals impairment, hypopigmented mycosis fungoides has also been described in Asian patients. The prognosis for hypopigmented mycosis fungoides is much better than for classical mycosis fungoides: hypopigmented mycosis fungoides is diagnosed when there are only patches of affected skin, and lesions usually will not progress beyond terminal stages, although they can persist for many years. Diagnosis should involve clinicopathologic correlation: skin biopsy analysis often reveals intense epidermotropism, characterized by haloed, large, and atypical CD8+ lymphocytes with convoluted nuclei, in contrast to mild to moderate dermal lymphocytic infiltrate. These CD8+ cells, which participate in T helper 1-mediated immune responses, prevent evolution to mycosis fungoides plaques and tumors and could be considered the main cause of the inhibition of melanogenesis. Therefore, hypopigmentation could be considered a marker of good prognosis for mycosis fungoides.
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spelling pubmed-39003472014-01-29 Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology Furlan, Fabricio Cecanho Sanches, José Antonio An Bras Dermatol Review Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most patients with hypopigmented mycosis fungoides are younger than patients typically diagnosed with classical mycosis fungoides. In addition to typical dark-skinned individuals impairment, hypopigmented mycosis fungoides has also been described in Asian patients. The prognosis for hypopigmented mycosis fungoides is much better than for classical mycosis fungoides: hypopigmented mycosis fungoides is diagnosed when there are only patches of affected skin, and lesions usually will not progress beyond terminal stages, although they can persist for many years. Diagnosis should involve clinicopathologic correlation: skin biopsy analysis often reveals intense epidermotropism, characterized by haloed, large, and atypical CD8+ lymphocytes with convoluted nuclei, in contrast to mild to moderate dermal lymphocytic infiltrate. These CD8+ cells, which participate in T helper 1-mediated immune responses, prevent evolution to mycosis fungoides plaques and tumors and could be considered the main cause of the inhibition of melanogenesis. Therefore, hypopigmentation could be considered a marker of good prognosis for mycosis fungoides. Sociedade Brasileira de Dermatologia 2013 /pmc/articles/PMC3900347/ /pubmed/24474105 http://dx.doi.org/10.1590/abd1806-4841.20132336 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Furlan, Fabricio Cecanho
Sanches, José Antonio
Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology
title Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology
title_full Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology
title_fullStr Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology
title_full_unstemmed Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology
title_short Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology
title_sort hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900347/
https://www.ncbi.nlm.nih.gov/pubmed/24474105
http://dx.doi.org/10.1590/abd1806-4841.20132336
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