Glucopyranosyl Lipid A Adjuvant Significantly Enhances HIV Specific T and B Cell Responses Elicited by a DNA-MVA-Protein Vaccine Regimen

Using a unique vaccine antigen matched and single HIV Clade C approach we have assessed the immunogenicity of a DNA-poxvirus-protein strategy in mice and rabbits, administering MVA and protein immunizations either sequentially or simultaneously and in the presence of a novel TLR4 adjuvant, GLA-AF. M...

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Detalles Bibliográficos
Autores principales: McKay, Paul F., Cope, Alethea V., Mann, Jamie F. S., Joseph, Sarah, Esteban, Mariano, Tatoud, Roger, Carter, Darrick, Reed, Steven G., Weber, Jonathan, Shattock, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900398/
https://www.ncbi.nlm.nih.gov/pubmed/24465426
http://dx.doi.org/10.1371/journal.pone.0084707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900398/
https://www.ncbi.nlm.nih.gov/pubmed/24465426
http://dx.doi.org/10.1371/journal.pone.0084707

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