The Incidence of Liver Injury in Uyghur Patients Treated for TB in Xinjiang Uyghur Autonomous Region, China, and Its Association with Hepatic Enzyme Polymorphisms NAT2, CYP2E1, GSTM1 and GSTT1

BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabolizing e...

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Detalles Bibliográficos
Autores principales: Xiang, Yang, Ma, Long, Wu, Weidong, Liu, Wei, Li, Yongguang, Zhu, Xia, Wang, Qian, Ma, Jinfeng, Cao, Mingqin, Yao, Xuemei, Yang, Lei, Wubuli, Atikaimu, Merle, Corinne, Milligan, Paul, Mao, Ying, Gu, Jiayi, Xin, Xiumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900431/
https://www.ncbi.nlm.nih.gov/pubmed/24465778
http://dx.doi.org/10.1371/journal.pone.0085905

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