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Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population
BACKGROUND: Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB). To predict the degree of risk for chronicity of HBV, this study determined associations with these SNPs. METHODS: The participants for this s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900446/ https://www.ncbi.nlm.nih.gov/pubmed/24465836 http://dx.doi.org/10.1371/journal.pone.0086007 |
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author | Posuwan, Nawarat Payungporn, Sunchai Tangkijvanich, Pisit Ogawa, Shintaro Murakami, Shuko Iijima, Sayuki Matsuura, Kentaro Shinkai, Noboru Watanabe, Tsunamasa Poovorawan, Yong Tanaka, Yasuhito |
author_facet | Posuwan, Nawarat Payungporn, Sunchai Tangkijvanich, Pisit Ogawa, Shintaro Murakami, Shuko Iijima, Sayuki Matsuura, Kentaro Shinkai, Noboru Watanabe, Tsunamasa Poovorawan, Yong Tanaka, Yasuhito |
author_sort | Posuwan, Nawarat |
collection | PubMed |
description | BACKGROUND: Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB). To predict the degree of risk for chronicity of HBV, this study determined associations with these SNPs. METHODS: The participants for this study were defined into 4 groups; HCC (n = 230), CHB (n = 219), resolved HBV infection (n = 113) and HBV uninfected subjects (n = 123). The HLA-DP SNPs (rs3077, rs9277378 and rs3128917), TCF19 SNP (rs1419881) and EHMT2 SNP (rs652888) were genotyped. RESULTS: Due to similar distribution of genotype frequencies in HCC and CHB, we combined these two groups (HBV carriers). The genotype distribution in HBV carriers relative to those who resolved HBV showed that rs3077 and rs9277378 were significantly associated with protective effects against CHB in minor dominant model (OR = 0.45, p<0.001 and OR = 0.47, p<0.001). The other SNPs rs3128917, rs1419881 and rs652888 were not associated with HBV carriers. CONCLUSIONS: Genetic variations of rs3077 and rs9277378, but not rs3128917, rs1419881 and rs652888, were significantly associated with HBV carriers relative to resolved HBV in Thai population. |
format | Online Article Text |
id | pubmed-3900446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39004462014-01-24 Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population Posuwan, Nawarat Payungporn, Sunchai Tangkijvanich, Pisit Ogawa, Shintaro Murakami, Shuko Iijima, Sayuki Matsuura, Kentaro Shinkai, Noboru Watanabe, Tsunamasa Poovorawan, Yong Tanaka, Yasuhito PLoS One Research Article BACKGROUND: Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB). To predict the degree of risk for chronicity of HBV, this study determined associations with these SNPs. METHODS: The participants for this study were defined into 4 groups; HCC (n = 230), CHB (n = 219), resolved HBV infection (n = 113) and HBV uninfected subjects (n = 123). The HLA-DP SNPs (rs3077, rs9277378 and rs3128917), TCF19 SNP (rs1419881) and EHMT2 SNP (rs652888) were genotyped. RESULTS: Due to similar distribution of genotype frequencies in HCC and CHB, we combined these two groups (HBV carriers). The genotype distribution in HBV carriers relative to those who resolved HBV showed that rs3077 and rs9277378 were significantly associated with protective effects against CHB in minor dominant model (OR = 0.45, p<0.001 and OR = 0.47, p<0.001). The other SNPs rs3128917, rs1419881 and rs652888 were not associated with HBV carriers. CONCLUSIONS: Genetic variations of rs3077 and rs9277378, but not rs3128917, rs1419881 and rs652888, were significantly associated with HBV carriers relative to resolved HBV in Thai population. Public Library of Science 2014-01-23 /pmc/articles/PMC3900446/ /pubmed/24465836 http://dx.doi.org/10.1371/journal.pone.0086007 Text en © 2014 Posuwan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Posuwan, Nawarat Payungporn, Sunchai Tangkijvanich, Pisit Ogawa, Shintaro Murakami, Shuko Iijima, Sayuki Matsuura, Kentaro Shinkai, Noboru Watanabe, Tsunamasa Poovorawan, Yong Tanaka, Yasuhito Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population |
title | Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population |
title_full | Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population |
title_fullStr | Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population |
title_full_unstemmed | Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population |
title_short | Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population |
title_sort | genetic association of human leukocyte antigens with chronicity or resolution of hepatitis b infection in thai population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900446/ https://www.ncbi.nlm.nih.gov/pubmed/24465836 http://dx.doi.org/10.1371/journal.pone.0086007 |
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