The Molecular Basis of Conformational Instability of the Ecdysone Receptor DNA Binding Domain Studied by In Silico and In Vitro Experiments

The heterodimer of the ecdysone receptor (EcR) and ultraspiracle (Usp), members of the nuclear receptors superfamily, regulates gene expression associated with molting and metamorphosis in insects. The DNA binding domains (DBDs) of the Usp and EcR play an important role in their DNA-dependent hetero...

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Detalles Bibliográficos
Autores principales: Szamborska-Gbur, Agnieszka, Rymarczyk, Grzegorz, Orłowski, Marek, Kuzynowski, Tomasz, Jakób, Michał, Dziedzic-Letka, Agnieszka, Górecki, Andrzej, Dobryszycki, Piotr, Ożyhar, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900457/
https://www.ncbi.nlm.nih.gov/pubmed/24465866
http://dx.doi.org/10.1371/journal.pone.0086052

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