Reduced Renal α-Klotho Expression in CKD Patients and Its Effect on Renal Phosphate Handling and Vitamin D Metabolism

Renal α-Klotho (α-KL) plays a fundamental role as a co-receptor for fibroblast growth factor 23 (FGF23), a phosphaturic hormone and regulator of 1,25(OH)(2) vitamin D(3) (1,25VitD(3)). Disruption of FGF23-α-KL signaling is thought to be an early hallmark of chronic kidney disease (CKD) involving red...

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Detalles Bibliográficos
Autores principales: Sakan, Hirokazu, Nakatani, Kimihiko, Asai, Osamu, Imura, Akihiro, Tanaka, Tomohiro, Yoshimoto, Shuhei, Iwamoto, Noriyuki, Kurumatani, Norio, Iwano, Masayuki, Nabeshima, Yo-ichi, Konishi, Noboru, Saito, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900516/
https://www.ncbi.nlm.nih.gov/pubmed/24466013
http://dx.doi.org/10.1371/journal.pone.0086301

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