Podocyte-Specific GLUT4-Deficient Mice Have Fewer and Larger Podocytes and Are Protected From Diabetic Nephropathy

Podocytes are a major component of the glomerular filtration barrier, and their ability to sense insulin is essential to prevent proteinuria. Here we identify the insulin downstream effector GLUT4 as a key modulator of podocyte function in diabetic nephropathy (DN). Mice with a podocyte-specific del...

Descripción completa

Detalles Bibliográficos
Autores principales: Guzman, Johanna, Jauregui, Alexandra N., Merscher-Gomez, Sandra, Maiguel, Dony, Muresan, Cristina, Mitrofanova, Alla, Diez-Sampedro, Ana, Szust, Joel, Yoo, Tae-Hyun, Villarreal, Rodrigo, Pedigo, Christopher, Molano, R. Damaris, Johnson, Kevin, Kahn, Barbara, Hartleben, Bjoern, Huber, Tobias B., Saha, Jharna, Burke, George W., Abel, E. Dale, Brosius, Frank C., Fornoni, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900538/
https://www.ncbi.nlm.nih.gov/pubmed/24101677
http://dx.doi.org/10.2337/db13-0752

Ejemplares similares

Ejemplares similares