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Autoantigen-Induced Focusing of Vβ13(+) T Cells Precedes Onset of Autoimmune Diabetes in the LEW.1WR1 Rat

The earliest events leading to autoimmune type 1 diabetes (T1D) are not known in any species. A T-cell receptor (TCR)-variable region, TCR-Vβ13, is required for susceptibility to autoimmune diabetes in rats, and selective depletion of Vβ13(+) T cells with an allele-specific monoclonal antibody preve...

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Detalles Bibliográficos
Autores principales:	Eberwine, Ryan A., Cort, Laura, Habib, Michael, Mordes, John P., Blankenhorn, Elizabeth P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900547/ https://www.ncbi.nlm.nih.gov/pubmed/24150607 http://dx.doi.org/10.2337/db13-0462

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