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Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia

Acute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechanism underlying their attenuation of postprandial glycemic excursions. However, this effect may diminish during prolonged use. We compared the effects of prolonged and int...

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Autores principales: Umapathysivam, Mahesh M., Lee, Michael Y., Jones, Karen L., Annink, Christopher E., Cousins, Caroline E., Trahair, Laurence G., Rayner, Chris K., Chapman, Marianne J., Nauck, Michael A., Horowitz, Michael, Deane, Adam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900552/
https://www.ncbi.nlm.nih.gov/pubmed/24089511
http://dx.doi.org/10.2337/db13-0893
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author Umapathysivam, Mahesh M.
Lee, Michael Y.
Jones, Karen L.
Annink, Christopher E.
Cousins, Caroline E.
Trahair, Laurence G.
Rayner, Chris K.
Chapman, Marianne J.
Nauck, Michael A.
Horowitz, Michael
Deane, Adam M.
author_facet Umapathysivam, Mahesh M.
Lee, Michael Y.
Jones, Karen L.
Annink, Christopher E.
Cousins, Caroline E.
Trahair, Laurence G.
Rayner, Chris K.
Chapman, Marianne J.
Nauck, Michael A.
Horowitz, Michael
Deane, Adam M.
author_sort Umapathysivam, Mahesh M.
collection PubMed
description Acute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechanism underlying their attenuation of postprandial glycemic excursions. However, this effect may diminish during prolonged use. We compared the effects of prolonged and intermittent stimulation of the GLP-1 receptor on gastric emptying and glycemia. Ten healthy men received intravenous saline (placebo) or GLP-1 (0.8 pmol/kg ⋅ min), as a continuous 24-h infusion (“prolonged”), two 4.5-h infusions separated by 20 h (“intermittent”), and a 4.5-h infusion (“acute”) in a randomized, double-blind, crossover fashion. Gastric emptying of a radiolabeled mashed potato meal was measured using scintigraphy. Acute GLP-1 markedly slowed gastric emptying. The magnitude of the slowing was attenuated with prolonged but maintained with intermittent infusions. GLP-1 potently diminished postprandial glycemia during acute and intermittent regimens. These observations suggest that short-acting GLP-1 agonists may be superior to long-acting agonists when aiming specifically to reduce postprandial glycemic excursions in the treatment of type 2 diabetes.
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spelling pubmed-39005522015-02-01 Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia Umapathysivam, Mahesh M. Lee, Michael Y. Jones, Karen L. Annink, Christopher E. Cousins, Caroline E. Trahair, Laurence G. Rayner, Chris K. Chapman, Marianne J. Nauck, Michael A. Horowitz, Michael Deane, Adam M. Diabetes Pharmacology and Therapeutics Acute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechanism underlying their attenuation of postprandial glycemic excursions. However, this effect may diminish during prolonged use. We compared the effects of prolonged and intermittent stimulation of the GLP-1 receptor on gastric emptying and glycemia. Ten healthy men received intravenous saline (placebo) or GLP-1 (0.8 pmol/kg ⋅ min), as a continuous 24-h infusion (“prolonged”), two 4.5-h infusions separated by 20 h (“intermittent”), and a 4.5-h infusion (“acute”) in a randomized, double-blind, crossover fashion. Gastric emptying of a radiolabeled mashed potato meal was measured using scintigraphy. Acute GLP-1 markedly slowed gastric emptying. The magnitude of the slowing was attenuated with prolonged but maintained with intermittent infusions. GLP-1 potently diminished postprandial glycemia during acute and intermittent regimens. These observations suggest that short-acting GLP-1 agonists may be superior to long-acting agonists when aiming specifically to reduce postprandial glycemic excursions in the treatment of type 2 diabetes. American Diabetes Association 2014-02 2014-01-16 /pmc/articles/PMC3900552/ /pubmed/24089511 http://dx.doi.org/10.2337/db13-0893 Text en © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Pharmacology and Therapeutics
Umapathysivam, Mahesh M.
Lee, Michael Y.
Jones, Karen L.
Annink, Christopher E.
Cousins, Caroline E.
Trahair, Laurence G.
Rayner, Chris K.
Chapman, Marianne J.
Nauck, Michael A.
Horowitz, Michael
Deane, Adam M.
Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
title Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
title_full Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
title_fullStr Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
title_full_unstemmed Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
title_short Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
title_sort comparative effects of prolonged and intermittent stimulation of the glucagon-like peptide 1 receptor on gastric emptying and glycemia
topic Pharmacology and Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900552/
https://www.ncbi.nlm.nih.gov/pubmed/24089511
http://dx.doi.org/10.2337/db13-0893
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