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Histone Deacetylase Inhibitors Selectively Target Homology Dependent DNA Repair Defective Cells and Elevate Non-Homologous Endjoining Activity

BACKGROUND: We have previously used the ATAD5-luciferase high-throughput screening assay to identify genotoxic compounds with potential chemotherapeutic capabilities. The successful identification of known genotoxic agents, including the histone deacetylase inhibitor (HDACi) trichostatin A (TSA), co...

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Detalles Bibliográficos
Autores principales:	Smith, Stephanie, Fox, Jennifer, Mejia, Marco, Ruangpradit, Wanvipa, Saberi, Alihossein, Kim, Sunmi, Choi, Yongjun, Oh, Sehyun, Wang, Yucai, Choi, Kyungho, Li, Lei, Hendrickson, Eric A., Takeda, Shunichi, Muller, Mark, Myung, Kyungjae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900704/ https://www.ncbi.nlm.nih.gov/pubmed/24466340 http://dx.doi.org/10.1371/journal.pone.0087203

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