MicroRNA-206: a Promising Theranostic Marker
MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases includin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900797/ https://www.ncbi.nlm.nih.gov/pubmed/24465270 http://dx.doi.org/10.7150/thno.7552 |
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author | Novák, Jan Kružliak, Peter Bienertová-Vašků, Julie Slabý, Ondřej Novák, Miroslav |
author_facet | Novák, Jan Kružliak, Peter Bienertová-Vašků, Julie Slabý, Ondřej Novák, Miroslav |
author_sort | Novák, Jan |
collection | PubMed |
description | MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-206, which belongs to the group of so-called “myomiRs”, is one of the most studied miRs thus far. In addition to being involved in skeletal muscle development and pathology, it has also been established that it is involved in the pathogenesis of numerous diseases including heart failure, chronic obstructive pulmonary disease, Alzheimer's disease and various types of cancers. The aim of this review is to provide a complex overview of microRNA-206, including regulating its expression, a brief description of its known functions in skeletal muscle and a complex overview of its roles in the biology and pathology of other tissues, emphasizing its significant diagnostic and therapeutic potential. |
format | Online Article Text |
id | pubmed-3900797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-39007972014-01-24 MicroRNA-206: a Promising Theranostic Marker Novák, Jan Kružliak, Peter Bienertová-Vašků, Julie Slabý, Ondřej Novák, Miroslav Theranostics Review MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-206, which belongs to the group of so-called “myomiRs”, is one of the most studied miRs thus far. In addition to being involved in skeletal muscle development and pathology, it has also been established that it is involved in the pathogenesis of numerous diseases including heart failure, chronic obstructive pulmonary disease, Alzheimer's disease and various types of cancers. The aim of this review is to provide a complex overview of microRNA-206, including regulating its expression, a brief description of its known functions in skeletal muscle and a complex overview of its roles in the biology and pathology of other tissues, emphasizing its significant diagnostic and therapeutic potential. Ivyspring International Publisher 2014-01-02 /pmc/articles/PMC3900797/ /pubmed/24465270 http://dx.doi.org/10.7150/thno.7552 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Review Novák, Jan Kružliak, Peter Bienertová-Vašků, Julie Slabý, Ondřej Novák, Miroslav MicroRNA-206: a Promising Theranostic Marker |
title | MicroRNA-206: a Promising Theranostic Marker |
title_full | MicroRNA-206: a Promising Theranostic Marker |
title_fullStr | MicroRNA-206: a Promising Theranostic Marker |
title_full_unstemmed | MicroRNA-206: a Promising Theranostic Marker |
title_short | MicroRNA-206: a Promising Theranostic Marker |
title_sort | microrna-206: a promising theranostic marker |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900797/ https://www.ncbi.nlm.nih.gov/pubmed/24465270 http://dx.doi.org/10.7150/thno.7552 |
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