Atrial fibrillation and microRNAs

Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmi...

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Autores principales: Santulli, Gaetano, Iaccarino, Guido, De Luca, Nicola, Trimarco, Bruno, Condorelli, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900852/
https://www.ncbi.nlm.nih.gov/pubmed/24478726
http://dx.doi.org/10.3389/fphys.2014.00015
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author Santulli, Gaetano
Iaccarino, Guido
De Luca, Nicola
Trimarco, Bruno
Condorelli, Gianluigi
author_facet Santulli, Gaetano
Iaccarino, Guido
De Luca, Nicola
Trimarco, Bruno
Condorelli, Gianluigi
author_sort Santulli, Gaetano
collection PubMed
description Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.
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spelling pubmed-39008522014-01-29 Atrial fibrillation and microRNAs Santulli, Gaetano Iaccarino, Guido De Luca, Nicola Trimarco, Bruno Condorelli, Gianluigi Front Physiol Physiology Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue. Frontiers Media S.A. 2014-01-24 /pmc/articles/PMC3900852/ /pubmed/24478726 http://dx.doi.org/10.3389/fphys.2014.00015 Text en Copyright © 2014 Santulli, Iaccarino, De Luca, Trimarco and Condorelli. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Santulli, Gaetano
Iaccarino, Guido
De Luca, Nicola
Trimarco, Bruno
Condorelli, Gianluigi
Atrial fibrillation and microRNAs
title Atrial fibrillation and microRNAs
title_full Atrial fibrillation and microRNAs
title_fullStr Atrial fibrillation and microRNAs
title_full_unstemmed Atrial fibrillation and microRNAs
title_short Atrial fibrillation and microRNAs
title_sort atrial fibrillation and micrornas
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900852/
https://www.ncbi.nlm.nih.gov/pubmed/24478726
http://dx.doi.org/10.3389/fphys.2014.00015
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