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Single-molecule tracking of the transcription cycle by sub-second RNA detection

Transcription is an inherently stochastic, noisy, and multi-step process, in which fluctuations at every step can cause variations in RNA synthesis, and affect physiology and differentiation decisions in otherwise identical cells. However, it has been an experimental challenge to directly link the s...

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Detalles Bibliográficos
Autores principales: Zhang, Zhengjian, Revyakin, Andrey, Grimm, Jonathan B, Lavis, Luke D, Tjian, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901038/
https://www.ncbi.nlm.nih.gov/pubmed/24473079
http://dx.doi.org/10.7554/eLife.01775