Regulation of the Autophagic Bcl-2/Beclin 1 Interaction

Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family (e....

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Autores principales: Decuypere, Jean-Paul, Parys, Jan B., Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901098/
https://www.ncbi.nlm.nih.gov/pubmed/24710477
http://dx.doi.org/10.3390/cells1030284
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author Decuypere, Jean-Paul
Parys, Jan B.
Bultynck, Geert
author_facet Decuypere, Jean-Paul
Parys, Jan B.
Bultynck, Geert
author_sort Decuypere, Jean-Paul
collection PubMed
description Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family (e.g., Bcl-2, Bcl-X(L) and Mcl-1). This binding is regulated by a variety of proteins and compounds that are able to enhance or inhibit the Bcl-2/Beclin 1 interaction in order to repress or activate autophagy, respectively. In this review we will focus on this interaction and discuss its characteristics, relevance and regulation.
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spelling pubmed-39010982014-04-07 Regulation of the Autophagic Bcl-2/Beclin 1 Interaction Decuypere, Jean-Paul Parys, Jan B. Bultynck, Geert Cells Review Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family (e.g., Bcl-2, Bcl-X(L) and Mcl-1). This binding is regulated by a variety of proteins and compounds that are able to enhance or inhibit the Bcl-2/Beclin 1 interaction in order to repress or activate autophagy, respectively. In this review we will focus on this interaction and discuss its characteristics, relevance and regulation. MDPI 2012-07-06 /pmc/articles/PMC3901098/ /pubmed/24710477 http://dx.doi.org/10.3390/cells1030284 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Decuypere, Jean-Paul
Parys, Jan B.
Bultynck, Geert
Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
title Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
title_full Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
title_fullStr Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
title_full_unstemmed Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
title_short Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
title_sort regulation of the autophagic bcl-2/beclin 1 interaction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901098/
https://www.ncbi.nlm.nih.gov/pubmed/24710477
http://dx.doi.org/10.3390/cells1030284
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