How Human Tumor Viruses Make Use of Autophagy

Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi’s Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect autophagy for their own ends. EBV and KSHV re...

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Detalles Bibliográficos
Autores principales: Pratt, Zachary L., Sugden, Bill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901112/
https://www.ncbi.nlm.nih.gov/pubmed/24710493
http://dx.doi.org/10.3390/cells1030617
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author Pratt, Zachary L.
Sugden, Bill
author_facet Pratt, Zachary L.
Sugden, Bill
author_sort Pratt, Zachary L.
collection PubMed
description Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi’s Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect autophagy for their own ends. EBV and KSHV regulate it during latent infections, a phase when no progeny virus is produced, while HBV and HCV use autophagy to promote their productive infections. Here we shall compare and contrast how these human tumor viruses regulate autophagy and what they gain by the appropriation of this cellular pathway.
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spelling pubmed-39011122014-04-07 How Human Tumor Viruses Make Use of Autophagy Pratt, Zachary L. Sugden, Bill Cells Review Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi’s Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect autophagy for their own ends. EBV and KSHV regulate it during latent infections, a phase when no progeny virus is produced, while HBV and HCV use autophagy to promote their productive infections. Here we shall compare and contrast how these human tumor viruses regulate autophagy and what they gain by the appropriation of this cellular pathway. MDPI 2012-08-27 /pmc/articles/PMC3901112/ /pubmed/24710493 http://dx.doi.org/10.3390/cells1030617 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Pratt, Zachary L.
Sugden, Bill
How Human Tumor Viruses Make Use of Autophagy
title How Human Tumor Viruses Make Use of Autophagy
title_full How Human Tumor Viruses Make Use of Autophagy
title_fullStr How Human Tumor Viruses Make Use of Autophagy
title_full_unstemmed How Human Tumor Viruses Make Use of Autophagy
title_short How Human Tumor Viruses Make Use of Autophagy
title_sort how human tumor viruses make use of autophagy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901112/
https://www.ncbi.nlm.nih.gov/pubmed/24710493
http://dx.doi.org/10.3390/cells1030617
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