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The Anti-Apoptotic Role of Neuroglobin
The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901133/ https://www.ncbi.nlm.nih.gov/pubmed/24710547 http://dx.doi.org/10.3390/cells1041133 |
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author | Brittain, Thomas |
author_facet | Brittain, Thomas |
author_sort | Brittain, Thomas |
collection | PubMed |
description | The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c. An integrated model, based on the various molecular actions of both neuroglobin and cytochrome c, is developed, which accounts for the cellular distribution of neuroglobin. |
format | Online Article Text |
id | pubmed-3901133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-39011332014-04-07 The Anti-Apoptotic Role of Neuroglobin Brittain, Thomas Cells Review The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c. An integrated model, based on the various molecular actions of both neuroglobin and cytochrome c, is developed, which accounts for the cellular distribution of neuroglobin. MDPI 2012-11-23 /pmc/articles/PMC3901133/ /pubmed/24710547 http://dx.doi.org/10.3390/cells1041133 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Brittain, Thomas The Anti-Apoptotic Role of Neuroglobin |
title | The Anti-Apoptotic Role of Neuroglobin |
title_full | The Anti-Apoptotic Role of Neuroglobin |
title_fullStr | The Anti-Apoptotic Role of Neuroglobin |
title_full_unstemmed | The Anti-Apoptotic Role of Neuroglobin |
title_short | The Anti-Apoptotic Role of Neuroglobin |
title_sort | anti-apoptotic role of neuroglobin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901133/ https://www.ncbi.nlm.nih.gov/pubmed/24710547 http://dx.doi.org/10.3390/cells1041133 |
work_keys_str_mv | AT brittainthomas theantiapoptoticroleofneuroglobin AT brittainthomas antiapoptoticroleofneuroglobin |