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Redox Mechanisms in Regulation of Adipocyte Differentiation: Beyond a General Stress Response

In this review, we summarize advances in our understanding of redox-sensitive mechanisms that regulate adipogenesis. Current evidence indicates that reactive oxygen species may act to promote both the initiation of adipocyte lineage commitment of precursor or stem cells, and the terminal differentia...

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Autores principales: Liu, Guei-Sheung, Chan, Elsa C., Higuchi, Masayoshi, Dusting, Gregory J., Jiang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901142/
https://www.ncbi.nlm.nih.gov/pubmed/24710538
http://dx.doi.org/10.3390/cells1040976
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author Liu, Guei-Sheung
Chan, Elsa C.
Higuchi, Masayoshi
Dusting, Gregory J.
Jiang, Fan
author_facet Liu, Guei-Sheung
Chan, Elsa C.
Higuchi, Masayoshi
Dusting, Gregory J.
Jiang, Fan
author_sort Liu, Guei-Sheung
collection PubMed
description In this review, we summarize advances in our understanding of redox-sensitive mechanisms that regulate adipogenesis. Current evidence indicates that reactive oxygen species may act to promote both the initiation of adipocyte lineage commitment of precursor or stem cells, and the terminal differentiation of preadipocytes to mature adipose cells. These can involve redox regulation of pathways mediated by receptor tyrosine kinases, peroxisome proliferator-activated receptor γ (PPARγ), PPARγ coactivator 1α (PGC-1α), AMP-activated protein kinase (AMPK), and CCAAT/enhancer binding protein β (C/EBPβ). However, the precise roles of ROS in adipogenesis in vivo remain controversial. More studies are needed to delineate the roles of reactive oxygen species and redox signaling mechanisms, which could be either positive or negative, in the pathogenesis of obesity and related metabolic disorders.
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spelling pubmed-39011422014-04-07 Redox Mechanisms in Regulation of Adipocyte Differentiation: Beyond a General Stress Response Liu, Guei-Sheung Chan, Elsa C. Higuchi, Masayoshi Dusting, Gregory J. Jiang, Fan Cells Review In this review, we summarize advances in our understanding of redox-sensitive mechanisms that regulate adipogenesis. Current evidence indicates that reactive oxygen species may act to promote both the initiation of adipocyte lineage commitment of precursor or stem cells, and the terminal differentiation of preadipocytes to mature adipose cells. These can involve redox regulation of pathways mediated by receptor tyrosine kinases, peroxisome proliferator-activated receptor γ (PPARγ), PPARγ coactivator 1α (PGC-1α), AMP-activated protein kinase (AMPK), and CCAAT/enhancer binding protein β (C/EBPβ). However, the precise roles of ROS in adipogenesis in vivo remain controversial. More studies are needed to delineate the roles of reactive oxygen species and redox signaling mechanisms, which could be either positive or negative, in the pathogenesis of obesity and related metabolic disorders. MDPI 2012-11-05 /pmc/articles/PMC3901142/ /pubmed/24710538 http://dx.doi.org/10.3390/cells1040976 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Liu, Guei-Sheung
Chan, Elsa C.
Higuchi, Masayoshi
Dusting, Gregory J.
Jiang, Fan
Redox Mechanisms in Regulation of Adipocyte Differentiation: Beyond a General Stress Response
title Redox Mechanisms in Regulation of Adipocyte Differentiation: Beyond a General Stress Response
title_full Redox Mechanisms in Regulation of Adipocyte Differentiation: Beyond a General Stress Response
title_fullStr Redox Mechanisms in Regulation of Adipocyte Differentiation: Beyond a General Stress Response
title_full_unstemmed Redox Mechanisms in Regulation of Adipocyte Differentiation: Beyond a General Stress Response
title_short Redox Mechanisms in Regulation of Adipocyte Differentiation: Beyond a General Stress Response
title_sort redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901142/
https://www.ncbi.nlm.nih.gov/pubmed/24710538
http://dx.doi.org/10.3390/cells1040976
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