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Cytoskeletal Regulation of Dermal Regeneration

Wound healing results in the repair of injured tissues however fibrosis and scar formation are, more often than not the unfortunate consequence of this process. The ability of lower order vertebrates and invertebrates to regenerate limbs and tissues has been all but lost in mammals; however, there a...

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Detalles Bibliográficos
Autores principales: Strudwick, Xanthe L., Cowin, Allison J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901152/
https://www.ncbi.nlm.nih.gov/pubmed/24710556
http://dx.doi.org/10.3390/cells1041313
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author Strudwick, Xanthe L.
Cowin, Allison J.
author_facet Strudwick, Xanthe L.
Cowin, Allison J.
author_sort Strudwick, Xanthe L.
collection PubMed
description Wound healing results in the repair of injured tissues however fibrosis and scar formation are, more often than not the unfortunate consequence of this process. The ability of lower order vertebrates and invertebrates to regenerate limbs and tissues has been all but lost in mammals; however, there are some instances where glimpses of mammalian regenerative capacity do exist. Here we describe the unlocked potential that exists in mammals that may help us understand the process of regeneration post-injury and highlight the potential role of the actin cytoskeleton in this process. The precise function and regulation of the cytoskeleton is critical to the success of the healing process and its manipulation may therefore facilitate regenerative healing. The gelsolin family of actin remodelling proteins in particular has been shown to have important functions in wound healing and family member Flightless I (Flii) is involved in both regeneration and repair. Understanding the interactions between different cytoskeletal proteins and their dynamic control of processes including cellular adhesion, contraction and motility may assist the development of therapeutics that will stimulate regeneration rather than repair.
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spelling pubmed-39011522014-04-07 Cytoskeletal Regulation of Dermal Regeneration Strudwick, Xanthe L. Cowin, Allison J. Cells Review Wound healing results in the repair of injured tissues however fibrosis and scar formation are, more often than not the unfortunate consequence of this process. The ability of lower order vertebrates and invertebrates to regenerate limbs and tissues has been all but lost in mammals; however, there are some instances where glimpses of mammalian regenerative capacity do exist. Here we describe the unlocked potential that exists in mammals that may help us understand the process of regeneration post-injury and highlight the potential role of the actin cytoskeleton in this process. The precise function and regulation of the cytoskeleton is critical to the success of the healing process and its manipulation may therefore facilitate regenerative healing. The gelsolin family of actin remodelling proteins in particular has been shown to have important functions in wound healing and family member Flightless I (Flii) is involved in both regeneration and repair. Understanding the interactions between different cytoskeletal proteins and their dynamic control of processes including cellular adhesion, contraction and motility may assist the development of therapeutics that will stimulate regeneration rather than repair. MDPI 2012-12-19 /pmc/articles/PMC3901152/ /pubmed/24710556 http://dx.doi.org/10.3390/cells1041313 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Strudwick, Xanthe L.
Cowin, Allison J.
Cytoskeletal Regulation of Dermal Regeneration
title Cytoskeletal Regulation of Dermal Regeneration
title_full Cytoskeletal Regulation of Dermal Regeneration
title_fullStr Cytoskeletal Regulation of Dermal Regeneration
title_full_unstemmed Cytoskeletal Regulation of Dermal Regeneration
title_short Cytoskeletal Regulation of Dermal Regeneration
title_sort cytoskeletal regulation of dermal regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901152/
https://www.ncbi.nlm.nih.gov/pubmed/24710556
http://dx.doi.org/10.3390/cells1041313
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