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MIF: Mood Improving/Inhibiting Factor?
Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression researc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901340/ https://www.ncbi.nlm.nih.gov/pubmed/24447830 http://dx.doi.org/10.1186/1742-2094-11-11 |
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author | Bloom, Joshua Al-Abed, Yousef |
author_facet | Bloom, Joshua Al-Abed, Yousef |
author_sort | Bloom, Joshua |
collection | PubMed |
description | Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression research, and, in particular, macrophage migration inhibitory factor (MIF) has been shown to be significant in depression physiology. In this review we summarize current research on MIF and depression. We highlight the arguments for MIF as a pro- and antidepressant species and discuss the potential implications for therapeutics. |
format | Online Article Text |
id | pubmed-3901340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39013402014-01-25 MIF: Mood Improving/Inhibiting Factor? Bloom, Joshua Al-Abed, Yousef J Neuroinflammation Review Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression research, and, in particular, macrophage migration inhibitory factor (MIF) has been shown to be significant in depression physiology. In this review we summarize current research on MIF and depression. We highlight the arguments for MIF as a pro- and antidepressant species and discuss the potential implications for therapeutics. BioMed Central 2014-01-21 /pmc/articles/PMC3901340/ /pubmed/24447830 http://dx.doi.org/10.1186/1742-2094-11-11 Text en Copyright © 2014 Bloom and Al-Abed; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Bloom, Joshua Al-Abed, Yousef MIF: Mood Improving/Inhibiting Factor? |
title | MIF: Mood Improving/Inhibiting Factor? |
title_full | MIF: Mood Improving/Inhibiting Factor? |
title_fullStr | MIF: Mood Improving/Inhibiting Factor? |
title_full_unstemmed | MIF: Mood Improving/Inhibiting Factor? |
title_short | MIF: Mood Improving/Inhibiting Factor? |
title_sort | mif: mood improving/inhibiting factor? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901340/ https://www.ncbi.nlm.nih.gov/pubmed/24447830 http://dx.doi.org/10.1186/1742-2094-11-11 |
work_keys_str_mv | AT bloomjoshua mifmoodimprovinginhibitingfactor AT alabedyousef mifmoodimprovinginhibitingfactor |