Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO

RNF4 (RING finger protein 4) is a STUbL [SUMO (small ubiquitin-related modifier)-targeted ubiquitin ligase] controlling PML (promyelocytic leukaemia) nuclear bodies, DNA double strand break repair and other nuclear functions. In the present paper, we describe that the sequence and spacing of the SIM...

Descripción completa

Detalles Bibliográficos
Autores principales: Keusekotten, Kirstin, Bade, Veronika N., Meyer-Teschendorf, Katrin, Sriramachandran, Annie Miriam, Fischer-Schrader, Katrin, Krause, Anke, Horst, Christiane, Schwarz, Günter, Hofmann, Kay, Dohmen, R. Jürgen, Praefcke, Gerrit J. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Accelerated Publication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901395/
https://www.ncbi.nlm.nih.gov/pubmed/24151981
http://dx.doi.org/10.1042/BJ20130753
_version_ 1782300846640332800
author Keusekotten, Kirstin
Bade, Veronika N.
Meyer-Teschendorf, Katrin
Sriramachandran, Annie Miriam
Fischer-Schrader, Katrin
Krause, Anke
Horst, Christiane
Schwarz, Günter
Hofmann, Kay
Dohmen, R. Jürgen
Praefcke, Gerrit J. K.
author_facet Keusekotten, Kirstin
Bade, Veronika N.
Meyer-Teschendorf, Katrin
Sriramachandran, Annie Miriam
Fischer-Schrader, Katrin
Krause, Anke
Horst, Christiane
Schwarz, Günter
Hofmann, Kay
Dohmen, R. Jürgen
Praefcke, Gerrit J. K.
author_sort Keusekotten, Kirstin
collection PubMed
description RNF4 (RING finger protein 4) is a STUbL [SUMO (small ubiquitin-related modifier)-targeted ubiquitin ligase] controlling PML (promyelocytic leukaemia) nuclear bodies, DNA double strand break repair and other nuclear functions. In the present paper, we describe that the sequence and spacing of the SIMs (SUMO-interaction motifs) in RNF4 regulate the avidity-driven recognition of substrate proteins carrying SUMO chains of variable length.
format Online
Article
Text
id pubmed-3901395
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-39013952014-01-28 Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO Keusekotten, Kirstin Bade, Veronika N. Meyer-Teschendorf, Katrin Sriramachandran, Annie Miriam Fischer-Schrader, Katrin Krause, Anke Horst, Christiane Schwarz, Günter Hofmann, Kay Dohmen, R. Jürgen Praefcke, Gerrit J. K. Biochem J Accelerated Publication RNF4 (RING finger protein 4) is a STUbL [SUMO (small ubiquitin-related modifier)-targeted ubiquitin ligase] controlling PML (promyelocytic leukaemia) nuclear bodies, DNA double strand break repair and other nuclear functions. In the present paper, we describe that the sequence and spacing of the SIMs (SUMO-interaction motifs) in RNF4 regulate the avidity-driven recognition of substrate proteins carrying SUMO chains of variable length. Portland Press Ltd. 2013-12-10 2014-01-01 /pmc/articles/PMC3901395/ /pubmed/24151981 http://dx.doi.org/10.1042/BJ20130753 Text en © 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Accelerated Publication
Keusekotten, Kirstin
Bade, Veronika N.
Meyer-Teschendorf, Katrin
Sriramachandran, Annie Miriam
Fischer-Schrader, Katrin
Krause, Anke
Horst, Christiane
Schwarz, Günter
Hofmann, Kay
Dohmen, R. Jürgen
Praefcke, Gerrit J. K.
Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO
title Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO
title_full Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO
title_fullStr Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO
title_full_unstemmed Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO
title_short Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO
title_sort multivalent interactions of the sumo-interaction motifs in ring finger protein 4 determine the specificity for chains of the sumo
topic Accelerated Publication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901395/
https://www.ncbi.nlm.nih.gov/pubmed/24151981
http://dx.doi.org/10.1042/BJ20130753
work_keys_str_mv AT keusekottenkirstin multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT badeveronikan multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT meyerteschendorfkatrin multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT sriramachandrananniemiriam multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT fischerschraderkatrin multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT krauseanke multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT horstchristiane multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT schwarzgunter multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT hofmannkay multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT dohmenrjurgen multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo
AT praefckegerritjk multivalentinteractionsofthesumointeractionmotifsinringfingerprotein4determinethespecificityforchainsofthesumo

Ejemplares similares