Cap-binding complex (CBC)

The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CBC (cap-binding complex). CBC has a key ro...

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Detalles Bibliográficos
Autores principales: Gonatopoulos-Pournatzis, Thomas, Cowling, Victoria H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901397/
https://www.ncbi.nlm.nih.gov/pubmed/24354960
http://dx.doi.org/10.1042/BJ20131214
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author Gonatopoulos-Pournatzis, Thomas
Cowling, Victoria H.
author_facet Gonatopoulos-Pournatzis, Thomas
Cowling, Victoria H.
author_sort Gonatopoulos-Pournatzis, Thomas
collection PubMed
description The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CBC (cap-binding complex). CBC has a key role in several gene expression mechanisms, including transcription, splicing, transcript export and translation. Gene expression can be regulated by signalling pathways which influence CBC function. The aim of the present review is to discuss the mechanisms by which CBC mediates and co-ordinates multiple gene expression events.
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spelling pubmed-39013972014-01-28 Cap-binding complex (CBC) Gonatopoulos-Pournatzis, Thomas Cowling, Victoria H. Biochem J Review Article The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CBC (cap-binding complex). CBC has a key role in several gene expression mechanisms, including transcription, splicing, transcript export and translation. Gene expression can be regulated by signalling pathways which influence CBC function. The aim of the present review is to discuss the mechanisms by which CBC mediates and co-ordinates multiple gene expression events. Portland Press Ltd. 2013-12-20 2014-01-15 /pmc/articles/PMC3901397/ /pubmed/24354960 http://dx.doi.org/10.1042/BJ20131214 Text en © 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gonatopoulos-Pournatzis, Thomas
Cowling, Victoria H.
Cap-binding complex (CBC)
title Cap-binding complex (CBC)
title_full Cap-binding complex (CBC)
title_fullStr Cap-binding complex (CBC)
title_full_unstemmed Cap-binding complex (CBC)
title_short Cap-binding complex (CBC)
title_sort cap-binding complex (cbc)
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901397/
https://www.ncbi.nlm.nih.gov/pubmed/24354960
http://dx.doi.org/10.1042/BJ20131214
work_keys_str_mv AT gonatopoulospournatzisthomas capbindingcomplexcbc
AT cowlingvictoriah capbindingcomplexcbc

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