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Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors
One of the key phenomena in the adaptive immune response to infection and immunization is affinity maturation, during which antibody genes are mutated and selected, typically resulting in a substantial increase in binding affinity to the eliciting antigen. Advances in technology on several fronts ha...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000Research
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901458/ https://www.ncbi.nlm.nih.gov/pubmed/24555054 http://dx.doi.org/10.12688/f1000research.2-103.v1 |