Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis

BACKGROUND: Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited. METHODS: The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported. RESULTS: Both patients with metastatic melanoma, aged 48 and 51 years...

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Detalles Bibliográficos
Autores principales: Alessandretti, Matheus, Buzaid, Antonio C., Brandão, Raphael, Brandão, Erika P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: December, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901601/
https://www.ncbi.nlm.nih.gov/pubmed/24474923
http://dx.doi.org/10.1159/000357401
Descripción
Sumario:BACKGROUND: Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited. METHODS: The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported. RESULTS: Both patients with metastatic melanoma, aged 48 and 51 years, had significant symptomatic and radiological improvement with low-dose bevacizumab treatment. Doses as low as 5 mg/kg every 6 weeks and 7.5 mg/kg i.v. every 4 weeks were used and were highly effective. CONCLUSIONS: Low-dose bevacizumab is a solid option in the management of edema associated with radiation necrosis.

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