Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis

BACKGROUND: Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited. METHODS: The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported. RESULTS: Both patients with metastatic melanoma, aged 48 and 51 years...

Descripción completa

Detalles Bibliográficos
Autores principales: Alessandretti, Matheus, Buzaid, Antonio C., Brandão, Raphael, Brandão, Erika P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: December, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901601/
https://www.ncbi.nlm.nih.gov/pubmed/24474923
http://dx.doi.org/10.1159/000357401
_version_ 1782300872510799872
author Alessandretti, Matheus
Buzaid, Antonio C.
Brandão, Raphael
Brandão, Erika P.
author_facet Alessandretti, Matheus
Buzaid, Antonio C.
Brandão, Raphael
Brandão, Erika P.
author_sort Alessandretti, Matheus
collection PubMed
description BACKGROUND: Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited. METHODS: The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported. RESULTS: Both patients with metastatic melanoma, aged 48 and 51 years, had significant symptomatic and radiological improvement with low-dose bevacizumab treatment. Doses as low as 5 mg/kg every 6 weeks and 7.5 mg/kg i.v. every 4 weeks were used and were highly effective. CONCLUSIONS: Low-dose bevacizumab is a solid option in the management of edema associated with radiation necrosis.
format Online
Article
Text
id pubmed-3901601
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-39016012014-01-28 Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis Alessandretti, Matheus Buzaid, Antonio C. Brandão, Raphael Brandão, Erika P. Case Rep Oncol Published online: December, 2013 BACKGROUND: Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited. METHODS: The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported. RESULTS: Both patients with metastatic melanoma, aged 48 and 51 years, had significant symptomatic and radiological improvement with low-dose bevacizumab treatment. Doses as low as 5 mg/kg every 6 weeks and 7.5 mg/kg i.v. every 4 weeks were used and were highly effective. CONCLUSIONS: Low-dose bevacizumab is a solid option in the management of edema associated with radiation necrosis. S. Karger AG 2013-12-07 /pmc/articles/PMC3901601/ /pubmed/24474923 http://dx.doi.org/10.1159/000357401 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: December, 2013
Alessandretti, Matheus
Buzaid, Antonio C.
Brandão, Raphael
Brandão, Erika P.
Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis
title Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis
title_full Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis
title_fullStr Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis
title_full_unstemmed Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis
title_short Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis
title_sort low-dose bevacizumab is effective in radiation-induced necrosis
topic Published online: December, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901601/
https://www.ncbi.nlm.nih.gov/pubmed/24474923
http://dx.doi.org/10.1159/000357401
work_keys_str_mv AT alessandrettimatheus lowdosebevacizumabiseffectiveinradiationinducednecrosis
AT buzaidantonioc lowdosebevacizumabiseffectiveinradiationinducednecrosis
AT brandaoraphael lowdosebevacizumabiseffectiveinradiationinducednecrosis
AT brandaoerikap lowdosebevacizumabiseffectiveinradiationinducednecrosis

Ejemplares similares