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HLA-A29-Positive Uveitis: Birdshot Chorioretinopathy, What Else?
Birdshot chorioretinopathy (BSCR) is a relatively rare form of uveitis, which is strongly correlated with the histocompatibility leukocyte antigen (HLA)-A29 class I type. Nevertheless, HLA typing is not diagnostic. The purpose of the present study was to retrospectively evaluate the ocular manifesta...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901631/ https://www.ncbi.nlm.nih.gov/pubmed/24474930 http://dx.doi.org/10.1159/000357276 |
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author | Zucchiatti, Ilaria Miserocchi, Elisabetta Sacconi, Riccardo Bandello, Francesco Modorati, Giulio |
author_facet | Zucchiatti, Ilaria Miserocchi, Elisabetta Sacconi, Riccardo Bandello, Francesco Modorati, Giulio |
author_sort | Zucchiatti, Ilaria |
collection | PubMed |
description | Birdshot chorioretinopathy (BSCR) is a relatively rare form of uveitis, which is strongly correlated with the histocompatibility leukocyte antigen (HLA)-A29 class I type. Nevertheless, HLA typing is not diagnostic. The purpose of the present study was to retrospectively evaluate the ocular manifestations associated with the presence of HLA-A29 other than typical BSCR. Charts of consecutive patients with a diagnosis of intraocular inflammation and who were found to be positive for the presence of HLA-A29 were retrospectively reviewed. Only 7 patients met the criteria for a definite diagnosis of BSCR. Among the other 11 patients, the disease was bilateral in 7 patients and unilateral in 4 patients. A definite diagnosis of the following conditions were found: intraocular and CNS lymphoma in 1 patient, posterior tubercular uveitis with occlusive vasculitis in 1 patient, latent ocular tuberculosis in 1 patient, Fuchs’ uveitis in 1 patient, herpetic panuveitis in 1 patient and HLA-B27 anterior uveitis in another patient. Although BSCR is strongly related to the HLA-A29 phenotype, and its presence confers a relative risk of disease, the definite diagnosis requires specific ocular characteristics. HLA-A29 typing alone is not a diagnostic requirement for the definite diagnosis of BSCR and should only be considered as a supportive finding. |
format | Online Article Text |
id | pubmed-3901631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-39016312014-01-28 HLA-A29-Positive Uveitis: Birdshot Chorioretinopathy, What Else? Zucchiatti, Ilaria Miserocchi, Elisabetta Sacconi, Riccardo Bandello, Francesco Modorati, Giulio Case Rep Ophthalmol Published online: December, 2013 Birdshot chorioretinopathy (BSCR) is a relatively rare form of uveitis, which is strongly correlated with the histocompatibility leukocyte antigen (HLA)-A29 class I type. Nevertheless, HLA typing is not diagnostic. The purpose of the present study was to retrospectively evaluate the ocular manifestations associated with the presence of HLA-A29 other than typical BSCR. Charts of consecutive patients with a diagnosis of intraocular inflammation and who were found to be positive for the presence of HLA-A29 were retrospectively reviewed. Only 7 patients met the criteria for a definite diagnosis of BSCR. Among the other 11 patients, the disease was bilateral in 7 patients and unilateral in 4 patients. A definite diagnosis of the following conditions were found: intraocular and CNS lymphoma in 1 patient, posterior tubercular uveitis with occlusive vasculitis in 1 patient, latent ocular tuberculosis in 1 patient, Fuchs’ uveitis in 1 patient, herpetic panuveitis in 1 patient and HLA-B27 anterior uveitis in another patient. Although BSCR is strongly related to the HLA-A29 phenotype, and its presence confers a relative risk of disease, the definite diagnosis requires specific ocular characteristics. HLA-A29 typing alone is not a diagnostic requirement for the definite diagnosis of BSCR and should only be considered as a supportive finding. S. Karger AG 2013-12-07 /pmc/articles/PMC3901631/ /pubmed/24474930 http://dx.doi.org/10.1159/000357276 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: December, 2013 Zucchiatti, Ilaria Miserocchi, Elisabetta Sacconi, Riccardo Bandello, Francesco Modorati, Giulio HLA-A29-Positive Uveitis: Birdshot Chorioretinopathy, What Else? |
title | HLA-A29-Positive Uveitis: Birdshot Chorioretinopathy, What Else? |
title_full | HLA-A29-Positive Uveitis: Birdshot Chorioretinopathy, What Else? |
title_fullStr | HLA-A29-Positive Uveitis: Birdshot Chorioretinopathy, What Else? |
title_full_unstemmed | HLA-A29-Positive Uveitis: Birdshot Chorioretinopathy, What Else? |
title_short | HLA-A29-Positive Uveitis: Birdshot Chorioretinopathy, What Else? |
title_sort | hla-a29-positive uveitis: birdshot chorioretinopathy, what else? |
topic | Published online: December, 2013 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901631/ https://www.ncbi.nlm.nih.gov/pubmed/24474930 http://dx.doi.org/10.1159/000357276 |
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