Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia

High plasma level of microparticles (MPs) deriving mainly from erythrocytes and platelets has been detected in sickle cell anemia (SCA) patients. Flow cytometry was used to determine the concentration of MPs in two groups of SCA patients exhibiting marked differences in painful vaso-occlusive crisis...

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Autores principales: Nebor, Danitza, Bowers, Andre, Connes, Philippe, Hardy-Dessources, Marie-Dominique, Knight-Madden, Jennifer, Cumming, Vanessa, Reid, Marvin, Romana, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901744/
https://www.ncbi.nlm.nih.gov/pubmed/24475257
http://dx.doi.org/10.1371/journal.pone.0087243
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author Nebor, Danitza
Bowers, Andre
Connes, Philippe
Hardy-Dessources, Marie-Dominique
Knight-Madden, Jennifer
Cumming, Vanessa
Reid, Marvin
Romana, Marc
author_facet Nebor, Danitza
Bowers, Andre
Connes, Philippe
Hardy-Dessources, Marie-Dominique
Knight-Madden, Jennifer
Cumming, Vanessa
Reid, Marvin
Romana, Marc
author_sort Nebor, Danitza
collection PubMed
description High plasma level of microparticles (MPs) deriving mainly from erythrocytes and platelets has been detected in sickle cell anemia (SCA) patients. Flow cytometry was used to determine the concentration of MPs in two groups of SCA patients exhibiting marked differences in painful vaso-occlusive crisis rates [a non-severe group (n = 17) and a severe group (n = 12)], and in a control group composed of healthy subjects (n = 20). A 3- to 4-fold increase of total MP plasma concentration was detected in SCA patients. Higher platelet-derived MPs concentration was detected in the severe SCA group while erythrocyte-derived MPs concentration was increased in the non-severe SCA patient group only. Our results suggest that plasma concentration of MPs shed by platelets is a biomarker of the vaso-occlusive phenotype-related severity.
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spelling pubmed-39017442014-01-28 Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia Nebor, Danitza Bowers, Andre Connes, Philippe Hardy-Dessources, Marie-Dominique Knight-Madden, Jennifer Cumming, Vanessa Reid, Marvin Romana, Marc PLoS One Research Article High plasma level of microparticles (MPs) deriving mainly from erythrocytes and platelets has been detected in sickle cell anemia (SCA) patients. Flow cytometry was used to determine the concentration of MPs in two groups of SCA patients exhibiting marked differences in painful vaso-occlusive crisis rates [a non-severe group (n = 17) and a severe group (n = 12)], and in a control group composed of healthy subjects (n = 20). A 3- to 4-fold increase of total MP plasma concentration was detected in SCA patients. Higher platelet-derived MPs concentration was detected in the severe SCA group while erythrocyte-derived MPs concentration was increased in the non-severe SCA patient group only. Our results suggest that plasma concentration of MPs shed by platelets is a biomarker of the vaso-occlusive phenotype-related severity. Public Library of Science 2014-01-24 /pmc/articles/PMC3901744/ /pubmed/24475257 http://dx.doi.org/10.1371/journal.pone.0087243 Text en © 2014 Nebor et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Nebor, Danitza
Bowers, Andre
Connes, Philippe
Hardy-Dessources, Marie-Dominique
Knight-Madden, Jennifer
Cumming, Vanessa
Reid, Marvin
Romana, Marc
Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia
title Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia
title_full Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia
title_fullStr Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia
title_full_unstemmed Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia
title_short Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia
title_sort plasma concentration of platelet-derived microparticles is related to painful vaso-occlusive phenotype severity in sickle cell anemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901744/
https://www.ncbi.nlm.nih.gov/pubmed/24475257
http://dx.doi.org/10.1371/journal.pone.0087243
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