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Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials

BACKGROUND AND AIM: Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect...

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Autores principales: Neelakantan, Nithya, Narayanan, Madanagopal, de Souza, Russell J, van Dam, Rob M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901758/
https://www.ncbi.nlm.nih.gov/pubmed/24438170
http://dx.doi.org/10.1186/1475-2891-13-7
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author Neelakantan, Nithya
Narayanan, Madanagopal
de Souza, Russell J
van Dam, Rob M
author_facet Neelakantan, Nithya
Narayanan, Madanagopal
de Souza, Russell J
van Dam, Rob M
author_sort Neelakantan, Nithya
collection PubMed
description BACKGROUND AND AIM: Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect of fenugreek intake on markers of glucose homeostasis. METHODS: PubMed, SCOPUS, the Cochrane Trials Registry, Web of Science, and BIOSIS were searched up to 29 Nov 2013 for trials of at least 1 week duration comparing intake of fenugreek seeds with a control intervention. Data on change in fasting blood glucose, 2 hour postload glucose, and HbA1c were pooled using random-effects models. RESULTS: A total of 10 trials were identified. Fenugreek significantly changed fasting blood glucose by -0.96 mmol/l (95% CI: -1.52, -0.40; I(2) = 80%; 10 trials), 2 hour postload glucose by -2.19 mmol/l (95% CI: -3.19, -1.19; I(2) = 71%; 7 trials) and HbA1c by -0.85% (95% CI: -1.49%, -0.22%; I(2) = 0%; 3 trials) as compared with control interventions. The considerable heterogeneity in study results was partly explained by diabetes status and dose: significant effects on fasting and 2 hr glucose were only found for studies that administered medium or high doses of fenugreek in persons with diabetes. Most of the trials were of low methodological quality. CONCLUSIONS: Results from clinical trials support beneficial effects of fenugreek seeds on glycemic control in persons with diabetes. However, trials with higher methodology quality using a well characterized fenugreek preparation of sufficient dose are needed to provide more conclusive evidence.
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spelling pubmed-39017582014-01-25 Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials Neelakantan, Nithya Narayanan, Madanagopal de Souza, Russell J van Dam, Rob M Nutr J Review BACKGROUND AND AIM: Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect of fenugreek intake on markers of glucose homeostasis. METHODS: PubMed, SCOPUS, the Cochrane Trials Registry, Web of Science, and BIOSIS were searched up to 29 Nov 2013 for trials of at least 1 week duration comparing intake of fenugreek seeds with a control intervention. Data on change in fasting blood glucose, 2 hour postload glucose, and HbA1c were pooled using random-effects models. RESULTS: A total of 10 trials were identified. Fenugreek significantly changed fasting blood glucose by -0.96 mmol/l (95% CI: -1.52, -0.40; I(2) = 80%; 10 trials), 2 hour postload glucose by -2.19 mmol/l (95% CI: -3.19, -1.19; I(2) = 71%; 7 trials) and HbA1c by -0.85% (95% CI: -1.49%, -0.22%; I(2) = 0%; 3 trials) as compared with control interventions. The considerable heterogeneity in study results was partly explained by diabetes status and dose: significant effects on fasting and 2 hr glucose were only found for studies that administered medium or high doses of fenugreek in persons with diabetes. Most of the trials were of low methodological quality. CONCLUSIONS: Results from clinical trials support beneficial effects of fenugreek seeds on glycemic control in persons with diabetes. However, trials with higher methodology quality using a well characterized fenugreek preparation of sufficient dose are needed to provide more conclusive evidence. BioMed Central 2014-01-18 /pmc/articles/PMC3901758/ /pubmed/24438170 http://dx.doi.org/10.1186/1475-2891-13-7 Text en Copyright © 2014 Neelakantan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Neelakantan, Nithya
Narayanan, Madanagopal
de Souza, Russell J
van Dam, Rob M
Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials
title Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials
title_full Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials
title_fullStr Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials
title_full_unstemmed Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials
title_short Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials
title_sort effect of fenugreek (trigonella foenum-graecum l.) intake on glycemia: a meta-analysis of clinical trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901758/
https://www.ncbi.nlm.nih.gov/pubmed/24438170
http://dx.doi.org/10.1186/1475-2891-13-7
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