Role of T(H)17 cytokines in the control of colorectal cancer

Immune/inflammatory cells infiltrate almost all human solid tumors and affect all stages of carcinogenesis as they produce different cytokine subsets. The overproduction of T(H)17 cytokines marks the early stages of colorectal carcinoma (CRC) and negatively influences the prognosis of CRC patients....

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Detalles Bibliográficos
Autores principales: De Simone, Veronica, Pallone, Francesco, Monteleone, Giovanni, Stolfi, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902118/
https://www.ncbi.nlm.nih.gov/pubmed/24498548
http://dx.doi.org/10.4161/onci.26617
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author De Simone, Veronica
Pallone, Francesco
Monteleone, Giovanni
Stolfi, Carmine
author_facet De Simone, Veronica
Pallone, Francesco
Monteleone, Giovanni
Stolfi, Carmine
author_sort De Simone, Veronica
collection PubMed
description Immune/inflammatory cells infiltrate almost all human solid tumors and affect all stages of carcinogenesis as they produce different cytokine subsets. The overproduction of T(H)17 cytokines marks the early stages of colorectal carcinoma (CRC) and negatively influences the prognosis of CRC patients. Studies with murine models of CRC have delineated the mechanisms by which T(H)17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs. In this review article, we discuss experimental data supporting the role of T(H)17 cytokines in the modulation of colorectal tumorigenesis.
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spelling pubmed-39021182014-02-04 Role of T(H)17 cytokines in the control of colorectal cancer De Simone, Veronica Pallone, Francesco Monteleone, Giovanni Stolfi, Carmine Oncoimmunology Review Immune/inflammatory cells infiltrate almost all human solid tumors and affect all stages of carcinogenesis as they produce different cytokine subsets. The overproduction of T(H)17 cytokines marks the early stages of colorectal carcinoma (CRC) and negatively influences the prognosis of CRC patients. Studies with murine models of CRC have delineated the mechanisms by which T(H)17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs. In this review article, we discuss experimental data supporting the role of T(H)17 cytokines in the modulation of colorectal tumorigenesis. Landes Bioscience 2013-12-01 2013-10-22 /pmc/articles/PMC3902118/ /pubmed/24498548 http://dx.doi.org/10.4161/onci.26617 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
De Simone, Veronica
Pallone, Francesco
Monteleone, Giovanni
Stolfi, Carmine
Role of T(H)17 cytokines in the control of colorectal cancer
title Role of T(H)17 cytokines in the control of colorectal cancer
title_full Role of T(H)17 cytokines in the control of colorectal cancer
title_fullStr Role of T(H)17 cytokines in the control of colorectal cancer
title_full_unstemmed Role of T(H)17 cytokines in the control of colorectal cancer
title_short Role of T(H)17 cytokines in the control of colorectal cancer
title_sort role of t(h)17 cytokines in the control of colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902118/
https://www.ncbi.nlm.nih.gov/pubmed/24498548
http://dx.doi.org/10.4161/onci.26617
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