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Quantitative influence of macromolecular crowding on gene regulation kinetics

We introduce macromolecular crowding quantitatively into the model for kinetics of gene regulation in Escherichia coli. We analyse and compute the specific-site searching time for 180 known transcription factors (TFs) regulating 1300 operons. The time is between 160 s (e.g. for SoxS M(w) = 12.91 kDa...

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Detalles Bibliográficos
Autores principales:	Tabaka, Marcin, Kalwarczyk, Tomasz, Hołyst, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902910/ https://www.ncbi.nlm.nih.gov/pubmed/24121687 http://dx.doi.org/10.1093/nar/gkt907

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