Cargando…

Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan

A transcriptional attenuation mechanism regulates expression of the bacterial tnaCAB operon. This mechanism requires ribosomal arrest induced by the regulatory nascent TnaC peptide in response to free L-tryptophan (L-Trp). In this study we demonstrate, using genetic and biochemical analyses, that in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martínez, Allyson K., Gordon, Emily, Sengupta, Arnab, Shirole, Nitin, Klepacki, Dorota, Martinez-Garriga, Blanca, Brown, Lewis M., Benedik, Michael J., Yanofsky, Charles, Mankin, Alexander S., Vazquez-Laslop, Nora, Sachs, Matthew S., Cruz-Vera, Luis R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902921/ https://www.ncbi.nlm.nih.gov/pubmed/24137004 http://dx.doi.org/10.1093/nar/gkt923

Ejemplares similares

Crucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function
por: Martínez, Allyson K., et al.
Publicado: (2012)

Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling
por: van der Stel, Anne-Xander, et al.
Publicado: (2021)

Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide
por: Su, Ting, et al.
Publicado: (2021)

Nascent peptide assists the ribosome in recognizing chemically distinct small molecules
por: Gupta, Pulkit, et al.
Publicado: (2016)

Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain
por: Koch, Miriam, et al.
Publicado: (2017)

Hierarchical recruitment into nascent ribosomes of assembly factors required for 27SB pre-rRNA processing in Saccharomyces cerevisiae
por: Talkish, Jason, et al.
Publicado: (2012)

Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation
por: Micic, Jelena, et al.
Publicado: (2022)

Yeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing
por: Gamalinda, Michael, et al.
Publicado: (2013)

Nascent RNA length dictates opposing effects of NusA on antitermination
por: Wells, Christopher D., et al.
Publicado: (2016)

Structural basis for TNA synthesis by an engineered TNA polymerase
por: Chim, Nicholas, et al.
Publicado: (2017)

Analysis of rRNA processing and translation in mammalian cells using a synthetic 18S rRNA expression system
por: Burman, Luke G., et al.
Publicado: (2012)

Cleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding
por: García-Ortega, Lucía, et al.
Publicado: (2010)

Trypanosome MTR4 is involved in rRNA processing
por: Cristodero, Marina, et al.
Publicado: (2007)

Elucidation of the assembly events required for the recruitment of Utp20, Imp4 and Bms1 onto nascent pre-ribosomes
por: Pérez-Fernández, Jorge, et al.
Publicado: (2011)

The complete chemical structure of Saccharomyces cerevisiae rRNA: partial pseudouridylation of U2345 in 25S rRNA by snoRNA snR9
por: Taoka, Masato, et al.
Publicado: (2016)

Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly
por: Huang, Shijie, et al.
Publicado: (2020)

In vivo probing of nascent RNA structures reveals principles of cotranscriptional folding
por: Incarnato, Danny, et al.
Publicado: (2017)

Binding of aminoglycoside antibiotics to helix 69 of 23S rRNA
por: Scheunemann, Ann E., et al.
Publicado: (2010)

The initial U3 snoRNA:pre-rRNA base pairing interaction required for pre-18S rRNA folding revealed by in vivo chemical probing
por: Dutca, Laura M., et al.
Publicado: (2011)

Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria
por: Hobbie, Sven N., et al.
Publicado: (2007)

Trans-splicing and RNA editing of LSU rRNA in Diplonema mitochondria
por: Valach, Matus, et al.
Publicado: (2014)

Identification of a new ribose methylation in the 18S rRNA of S. cerevisiae
por: Yang, Jun, et al.
Publicado: (2015)

Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes
por: Segerstolpe, Åsa, et al.
Publicado: (2008)

A small nucleolar RNA functions in rRNA processing in Caenorhabditis elegans
por: Hokii, Yusuke, et al.
Publicado: (2010)

Dynamics of nascent mRNA folding and RNA–protein interactions: an alternative TAR RNA structure is involved in the control of HIV-1 mRNA transcription
por: Richter, Sara N., et al.
Publicado: (2006)

Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides
por: Martins, Rodrigo Prado, et al.
Publicado: (2019)

Dicer dependent tRNA derived small RNAs promote nascent RNA silencing
por: Di Fazio, Arianna, et al.
Publicado: (2022)

The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing
por: Hölzel, Michael, et al.
Publicado: (2007)

Changes in the conformation of 5S rRNA cause alterations in principal functions of the ribosomal nanomachine
por: Kouvela, Ekaterini C., et al.
Publicado: (2007)

The NIP7 protein is required for accurate pre-rRNA processing in human cells
por: Morello, Luis G., et al.
Publicado: (2011)

Differences in the path to exit the ribosome across the three domains of life
por: Dao Duc, Khanh, et al.
Publicado: (2019)

An in Vitro Selection System for TNA
por: Ichida, Justin K., et al.
Publicado: (2005)

EF-Tu dynamics during pre-translocation complex formation: EF-Tu·GDP exits the ribosome via two different pathways
por: Liu, Wei, et al.
Publicado: (2015)

RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmA(II) in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility
por: Shoji, Tatsuma, et al.
Publicado: (2015)

rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance
por: Rakauskaitė, Rasa, et al.
Publicado: (2008)

Elastic properties of ribosomal RNA building blocks: molecular dynamics of the GTPase-associated center rRNA
por: Rázga, Filip, et al.
Publicado: (2007)

A minimized rRNA-binding site for ribosomal protein S4 and its implications for 30S assembly
por: Bellur, Deepti L., et al.
Publicado: (2009)

Ribosomal protein L35 is required for 27SB pre-rRNA processing in Saccharomyces cerevisiae
por: Babiano, Reyes, et al.
Publicado: (2010)

Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA
por: Kimura, Satoshi, et al.
Publicado: (2010)

Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA
por: Preti, Milena, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_p03bqsjkqmo6ulu1nad4g8ol6m