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Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity

SMARCAL1 promotes the repair and restart of damaged replication forks. Either overexpression or silencing SMARCAL1 causes the accumulation of replication-associated DNA damage. SMARCAL1 is heavily phosphorylated. Here we identify multiple phosphorylation sites, including S889, which is phosphorylate...

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Detalles Bibliográficos
Autores principales:	Carroll, Clinton, Bansbach, Carol E., Zhao, Runxiang, Jung, Sung Yun, Qin, Jun, Cortez, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902923/ https://www.ncbi.nlm.nih.gov/pubmed/24150942 http://dx.doi.org/10.1093/nar/gkt929

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