Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target

hDIS3 is a mainly nuclear, catalytic subunit of the human exosome complex, containing exonucleolytic (RNB) and endonucleolytic (PIN) active domains. Mutations in hDIS3 have been found in ∼10% of patients with multiple myeloma (MM). Here, we show that these mutations interfere with hDIS3 exonucleolyt...

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Detalles Bibliográficos
Autores principales: Tomecki, Rafal, Drazkowska, Karolina, Kucinski, Iwo, Stodus, Krystian, Szczesny, Roman J., Gruchota, Jakub, Owczarek, Ewelina P., Kalisiak, Katarzyna, Dziembowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902924/
https://www.ncbi.nlm.nih.gov/pubmed/24150935
http://dx.doi.org/10.1093/nar/gkt930

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