Cargando…

The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing

Conventional paradigm ascribes the cell proliferative function of the human oncoprotein mouse double minute2 (MDM2) primarily to its ability to degrade p53. Here we report that in the absence of p53, MDM2 induces replication stress eliciting an early S-phase checkpoint response to inhibit further fi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frum, Rebecca A., Singh, Shilpa, Vaughan, Catherine, Mukhopadhyay, Nitai D., Grossman, Steven R., Windle, Brad, Deb, Sumitra, Deb, Swati Palit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902934/ https://www.ncbi.nlm.nih.gov/pubmed/24163099 http://dx.doi.org/10.1093/nar/gkt944

Ejemplares similares

Do replication forks control late origin firing in Saccharomyces cerevisiae?
por: Ma, Emilie, et al.
Publicado: (2012)

Stimulation of adaptive gene amplification by origin firing under replication fork constraint
por: Whale, Alex J, et al.
Publicado: (2022)

Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells
por: Sugimoto, Nozomi, et al.
Publicado: (2018)

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts
por: Gaggioli, Vincent, et al.
Publicado: (2013)

New origin firing is inhibited by APC/C(Cdh1) activation in S-phase after severe replication stress
por: Ercilla, Amaia, et al.
Publicado: (2016)

The progression of replication forks at natural replication barriers in live bacteria
por: Moolman, M. Charl, et al.
Publicado: (2016)

Gain‐of‐function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells
por: Vaughan, Catherine A., et al.
Publicado: (2017)

Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus
por: Ciardo, Diletta, et al.
Publicado: (2021)

Direct removal of RNA polymerase barriers to replication by accessory replicative helicases
por: Hawkins, Michelle, et al.
Publicado: (2019)

Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication
por: Rajala, Nina, et al.
Publicado: (2014)

BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression
por: Cohen, Stephanie M., et al.
Publicado: (2010)

Bacteriophage SPP1 DNA replication strategies promote viral and disable host replication in vitro
por: Seco, Elena M., et al.
Publicado: (2013)

Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
por: Morin, José A., et al.
Publicado: (2015)

Shaping the landscape of the Escherichia coli chromosome: replication-transcription encounters in cells with an ectopic replication origin
por: Ivanova, Darja, et al.
Publicado: (2015)

Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A
por: Tsaalbi-Shtylik, Anastasia, et al.
Publicado: (2014)

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability
por: Hjorth-Jensen, Kim, et al.
Publicado: (2018)

SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms
por: Pedersen, Ida Benedikte, et al.
Publicado: (2017)

Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability
por: Utani, Koichi, et al.
Publicado: (2017)

UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity
por: Cipolla, Lina, et al.
Publicado: (2019)

Replicative resolution of integron cassette insertion
por: Loot, Céline, et al.
Publicado: (2012)

Stability of blocked replication forks in vivo
por: Mettrick, Karla A., et al.
Publicado: (2016)

Improved artificial origins for phage Φ29 terminal protein-primed replication. Insights into early replication events
por: Gella, Pablo, et al.
Publicado: (2014)

Replication dynamics of individual loci in single living cells reveal changes in the degree of replication stochasticity through S phase
por: Duriez, Bénédicte, et al.
Publicado: (2019)

Ectopic RNF168 expression promotes break-induced replication-like DNA synthesis at stalled replication forks
por: Krais, John J, et al.
Publicado: (2020)

Plasmid replication based on the T7 origin of replication requires a T7 RNAP variant and inactivation of ribonuclease H
por: Becker, Katja, et al.
Publicado: (2021)

Tumour suppressor ING1b maintains genomic stability upon replication stress
por: Wong, Ronald P. C., et al.
Publicado: (2011)

CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation
por: Elvers, Ingegerd, et al.
Publicado: (2012)

Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions
por: Wu, Xia, et al.
Publicado: (2018)

Phosphorylation of SRSF1 is modulated by replicational stress
por: Leva, Valentina, et al.
Publicado: (2012)

The sub-cellular localization of Sulfolobus DNA replication
por: Gristwood, Tamzin, et al.
Publicado: (2012)

Inhibition of DNA replication initiation by silver nanoclusters
por: Tao, Yu, et al.
Publicado: (2021)

Chromosomal over-replication in Escherichia coli recG cells is triggered by replication fork fusion and amplified if replichore symmetry is disturbed
por: Midgley-Smith, Sarah L, et al.
Publicado: (2018)

Dynamic switching of crotonylation to ubiquitination of H2A at lysine 119 attenuates transcription–replication conflicts caused by replication stress
por: Hao, Shuailin, et al.
Publicado: (2022)

MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity
por: Margara, Lucía M., et al.
Publicado: (2016)

Locus-specific transcription silencing at the FHIT gene suppresses replication stress-induced copy number variant formation and associated replication delay
por: Park, So Hae, et al.
Publicado: (2021)

Changes in the architecture and abundance of replication intermediates delineate the chronology of DNA damage tolerance pathways at UV-stalled replication forks in human cells
por: Benureau, Yann, et al.
Publicado: (2022)

Overcoming natural replication barriers: differential helicase requirements
por: Anand, Ranjith P., et al.
Publicado: (2012)

A role for chromatin remodellers in replication of damaged DNA
por: Niimi, Atsuko, et al.
Publicado: (2012)

Bacillus subtilis RarA modulates replication restart
por: Carrasco, Begoña, et al.
Publicado: (2018)

Replication studies of carboxymethylated DNA lesions in human cells
por: Wu, Jun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_esa2a2a11iue7h15m1o5a74smi