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Nuclease-mediated gene editing by homologous recombination of the human globin locus

Tal-effector nucleases (TALENs) are engineered proteins that can stimulate precise genome editing through specific DNA double-strand breaks. Sickle cell disease and β-thalassemia are common genetic disorders caused by mutations in β-globin, and we engineered a pair of highly active TALENs that induc...

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Detalles Bibliográficos
Autores principales:	Voit, Richard A., Hendel, Ayal, Pruett-Miller, Shondra M., Porteus, Matthew H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902937/ https://www.ncbi.nlm.nih.gov/pubmed/24157834 http://dx.doi.org/10.1093/nar/gkt947

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