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Midlife Hypertensive Status and Cognitive Function 20 Years Later: The Southall and Brent Revisited Study
Objectives: To investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later. Design: Cohort study. Setting: Two areas (Southall and Brent) of northwest London. Participants: Survey samples of a multiethnic po...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902992/ https://www.ncbi.nlm.nih.gov/pubmed/24028355 http://dx.doi.org/10.1111/jgs.12416 |
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author | Taylor, Clare Tillin, Therese Chaturvedi, Nish Dewey, Michael Ferri, Cleusa P Hughes, Alun Prince, Martin Richards, Marcus Shah, Ajit Stewart, Robert |
author_facet | Taylor, Clare Tillin, Therese Chaturvedi, Nish Dewey, Michael Ferri, Cleusa P Hughes, Alun Prince, Martin Richards, Marcus Shah, Ajit Stewart, Robert |
author_sort | Taylor, Clare |
collection | PubMed |
description | Objectives: To investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later. Design: Cohort study. Setting: Two areas (Southall and Brent) of northwest London. Participants: Survey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later. Measurements: Comprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status. Results: In 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged ≥50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups. Conclusion: Low and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk. |
format | Online Article Text |
id | pubmed-3902992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39029922014-01-29 Midlife Hypertensive Status and Cognitive Function 20 Years Later: The Southall and Brent Revisited Study Taylor, Clare Tillin, Therese Chaturvedi, Nish Dewey, Michael Ferri, Cleusa P Hughes, Alun Prince, Martin Richards, Marcus Shah, Ajit Stewart, Robert J Am Geriatr Soc Clinical Investigations Objectives: To investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later. Design: Cohort study. Setting: Two areas (Southall and Brent) of northwest London. Participants: Survey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later. Measurements: Comprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status. Results: In 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged ≥50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups. Conclusion: Low and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk. Blackwell Publishing Ltd 2013-09 2013-08-26 /pmc/articles/PMC3902992/ /pubmed/24028355 http://dx.doi.org/10.1111/jgs.12416 Text en © 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial–NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Clinical Investigations Taylor, Clare Tillin, Therese Chaturvedi, Nish Dewey, Michael Ferri, Cleusa P Hughes, Alun Prince, Martin Richards, Marcus Shah, Ajit Stewart, Robert Midlife Hypertensive Status and Cognitive Function 20 Years Later: The Southall and Brent Revisited Study |
title | Midlife Hypertensive Status and Cognitive Function 20 Years Later: The Southall and Brent Revisited Study |
title_full | Midlife Hypertensive Status and Cognitive Function 20 Years Later: The Southall and Brent Revisited Study |
title_fullStr | Midlife Hypertensive Status and Cognitive Function 20 Years Later: The Southall and Brent Revisited Study |
title_full_unstemmed | Midlife Hypertensive Status and Cognitive Function 20 Years Later: The Southall and Brent Revisited Study |
title_short | Midlife Hypertensive Status and Cognitive Function 20 Years Later: The Southall and Brent Revisited Study |
title_sort | midlife hypertensive status and cognitive function 20 years later: the southall and brent revisited study |
topic | Clinical Investigations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902992/ https://www.ncbi.nlm.nih.gov/pubmed/24028355 http://dx.doi.org/10.1111/jgs.12416 |
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