Cargando…

Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes

The aim of the present study was to determine whether the endothelial dysfunction associated with CAD (coronary artery disease) and T2D (Type 2 diabetes mellitus) is concomitant with elevated mtROS (mitochondrial reactive oxygen species) production in the endothelium and establish if this, in turn,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mackenzie, Ruth M., Salt, Ian P., Miller, William H., Logan, Angela, Ibrahim, Hagar A., Degasperi, Andrea, Dymott, Jane A., Hamilton, Carlene A., Murphy, Michael P., Delles, Christian, Dominiczak, Anna F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903000/ https://www.ncbi.nlm.nih.gov/pubmed/23057846 http://dx.doi.org/10.1042/CS20120239

Ejemplares similares

Reduced LDL-cholesterol levels in patients with coronary artery disease are paralelled by improved endothelial function: An observational study in patients from 2003 and 2007
por: Delles, Christian, et al.
Publicado: (2010)

Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium
por: Zinovkin, Roman A., et al.
Publicado: (2014)

Evaluation of the systemic micro- and macrovasculature in stable angina: A case-control study
por: Neisius, Ulf, et al.
Publicado: (2017)

Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease
por: Rossi, Sabrina H, et al.
Publicado: (2013)

Gene expression profiling in whole blood of patients with coronary artery disease
por: Taurino, Chiara, et al.
Publicado: (2010)

Urine proteomics in the diagnosis of stable angina
por: Neisius, Ulf, et al.
Publicado: (2016)

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase
por: Wang, Qilong, et al.
Publicado: (2011)

AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production
por: Reihill, James A., et al.
Publicado: (2007)

Effects of reactive oxygen species and neutrophils on endothelium-dependent relaxation of rat thoracic aorta
por: Bauer, Viktor, et al.
Publicado: (2011)

Elevated cAMP opposes (TNF-α)-induced loss in the barrier integrity of corneal endothelium
por: Shivanna, Mahesh, et al.
Publicado: (2010)

The Endothelium and Endothelin: Beyond Vascular Reactivity
por: Hassan, Walid
Publicado: (2006)

Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation
por: Rodríguez, Claudia, et al.
Publicado: (2020)

Recombinant activated protein C in sepsis: endothelium protection or endothelium therapy?
por: Regnault, Veronique, et al.
Publicado: (2007)

Reactive Oxygen Species-Induced Impairment of Endothelium-Dependent Relaxations in Rat Aortic Rings: Protection by Methanolic Extracts of Phoebe grandis
por: Yeh-Siang, Lau, et al.
Publicado: (2011)

Novel Biomarkers for Predicting Preeclampsia
por: Carty, David M., et al.
Publicado: (2008)

Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways
por: Tian, Zi-Han, et al.
Publicado: (2018)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
por: Chen, Suet Ching, et al.
Publicado: (2017)

Effect of ketorolac and diclofenac on the impairment of endothelium-dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta
por: Lee, Seung Yoon, et al.
Publicado: (2010)

How mitochondria produce reactive oxygen species
por: Murphy, Michael P.
Publicado: (2008)

The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells
por: Reihill, James A, et al.
Publicado: (2011)

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly
por: Hinchy, Elizabeth C., et al.
Publicado: (2018)

Antioxidant effects of methylprednisolone and hydrocortisone on the impairment of endothelium dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta
por: Lee, Hee Jong, et al.
Publicado: (2013)

Moving Beyond the Endothelium is Still Challenging-Complex Interplay between Endothelin and Reactive Oxygen Species in Pulmonary Arterial Hypertension
por: Chung, Hyemoon, et al.
Publicado: (2019)

Endothelium activation during prolonged extra-corporeal circulation
por: Adamik, B, et al.
Publicado: (1998)

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
por: Heathcote, Helen R., et al.
Publicado: (2016)

Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel
por: Lanaspa, Miguel A., et al.
Publicado: (2015)

Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells
por: Park, Cheol, et al.
Publicado: (2019)

Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species
por: Li, Xiaoling, et al.
Publicado: (2021)

A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase
por: Strembitska, Anastasiya, et al.
Publicado: (2018)

Rhus coriaria L. (Sumac) Evokes Endothelium-Dependent Vasorelaxation of Rat Aorta: Involvement of the cAMP and cGMP Pathways
por: Anwar, Mohammad A., et al.
Publicado: (2018)

Proteins Needed to Activate a Transcriptional Response to the Reactive Oxygen Species Singlet Oxygen
por: Nam, Tae-Wook, et al.
Publicado: (2013)

Platelets and the Endothelium: Active Participants in Severe COVID-19 Infection
por: Parker, William A.E., et al.
Publicado: (2021)

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation
por: Gowans, Graeme J., et al.
Publicado: (2013)

cAMP activates the generation of reactive oxygen species and inhibits the secretion of IL-6 in peripheral blood mononuclear cells from type 2 diabetic patients
por: Isoni, Camila Armond, et al.
Publicado: (2009)

COVID-19 and the endothelium
por: Jung, F., et al.
Publicado: (2020)

Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium
por: Lockett, Angelia D., et al.
Publicado: (2014)

Inside-Out Regulation of ICAM-1 Dynamics in TNF-α-Activated Endothelium
por: van Buul, Jaap D., et al.
Publicado: (2010)

Top quark physics with ATLAS &amp;amp;amp;amp; CMS
por: Onofre, A
Publicado: (2009)

Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation
por: Saxena, Shobhit, et al.
Publicado: (2016)

Hepatic Abscess in Children
por: Dymott, Donald F.
Publicado: (1887)

Cannot write session to /tmp/vufind_sessions/sess_beipk3arq79lfop9kl58qp0216