Cargando…
Isolation and Structure Elucidation of Pentahydroxyscirpene, a Trichothecene Fusarium Mycotoxin
[Image: see text] Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY exper...
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society and American
Society of Pharmacognosy
2013
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903343/ https://www.ncbi.nlm.nih.gov/pubmed/24367932 http://dx.doi.org/10.1021/np4008365 |
| _version_ | 1782301082019430400 |
|---|---|
| author | Fruhmann, Philipp Mikula, Hannes Wiesenberger, Gerlinde Varga, Elisabeth Lumpi, Daniel Stöger, Berthold Häubl, Georg Lemmens, Marc Berthiller, Franz Krska, Rudolf Adam, Gerhard Hametner, Christian Fröhlich, Johannes |
| author_facet | Fruhmann, Philipp Mikula, Hannes Wiesenberger, Gerlinde Varga, Elisabeth Lumpi, Daniel Stöger, Berthold Häubl, Georg Lemmens, Marc Berthiller, Franz Krska, Rudolf Adam, Gerhard Hametner, Christian Fröhlich, Johannes |
| author_sort | Fruhmann, Philipp |
| collection | PubMed |
| description | [Image: see text] Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY experiments supported by quantum chemical calculations. In vitro toxicity tests showed that pentahydroxyscirpene inhibits protein synthesis as do other trichothecenes. |
| format | Online Article Text |
| id | pubmed-3903343 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | American Chemical
Society and American
Society of Pharmacognosy |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-39033432014-01-29 Isolation and Structure Elucidation of Pentahydroxyscirpene, a Trichothecene Fusarium Mycotoxin Fruhmann, Philipp Mikula, Hannes Wiesenberger, Gerlinde Varga, Elisabeth Lumpi, Daniel Stöger, Berthold Häubl, Georg Lemmens, Marc Berthiller, Franz Krska, Rudolf Adam, Gerhard Hametner, Christian Fröhlich, Johannes J Nat Prod [Image: see text] Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY experiments supported by quantum chemical calculations. In vitro toxicity tests showed that pentahydroxyscirpene inhibits protein synthesis as do other trichothecenes. American Chemical Society and American Society of Pharmacognosy 2013-12-24 2014-01-24 /pmc/articles/PMC3903343/ /pubmed/24367932 http://dx.doi.org/10.1021/np4008365 Text en Copyright © 2013 American Chemical Society and American Society of Pharmacognosy Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
| spellingShingle | Fruhmann, Philipp Mikula, Hannes Wiesenberger, Gerlinde Varga, Elisabeth Lumpi, Daniel Stöger, Berthold Häubl, Georg Lemmens, Marc Berthiller, Franz Krska, Rudolf Adam, Gerhard Hametner, Christian Fröhlich, Johannes Isolation and Structure Elucidation of Pentahydroxyscirpene, a Trichothecene Fusarium Mycotoxin |
| title | Isolation
and Structure Elucidation of Pentahydroxyscirpene,
a Trichothecene Fusarium Mycotoxin |
| title_full | Isolation
and Structure Elucidation of Pentahydroxyscirpene,
a Trichothecene Fusarium Mycotoxin |
| title_fullStr | Isolation
and Structure Elucidation of Pentahydroxyscirpene,
a Trichothecene Fusarium Mycotoxin |
| title_full_unstemmed | Isolation
and Structure Elucidation of Pentahydroxyscirpene,
a Trichothecene Fusarium Mycotoxin |
| title_short | Isolation
and Structure Elucidation of Pentahydroxyscirpene,
a Trichothecene Fusarium Mycotoxin |
| title_sort | isolation
and structure elucidation of pentahydroxyscirpene,
a trichothecene fusarium mycotoxin |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903343/ https://www.ncbi.nlm.nih.gov/pubmed/24367932 http://dx.doi.org/10.1021/np4008365 |
| work_keys_str_mv | AT fruhmannphilipp isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT mikulahannes isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT wiesenbergergerlinde isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT vargaelisabeth isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT lumpidaniel isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT stogerberthold isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT haublgeorg isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT lemmensmarc isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT berthillerfranz isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT krskarudolf isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT adamgerhard isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT hametnerchristian isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin AT frohlichjohannes isolationandstructureelucidationofpentahydroxyscirpeneatrichothecenefusariummycotoxin |