Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells

BACKGROUND: Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to identify genes that are synthetically lethal...

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Detalles Bibliográficos
Autores principales: Kang, Jian, Sergio, C Marcelo, Sutherland, Robert L, Musgrove, Elizabeth A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903446/
https://www.ncbi.nlm.nih.gov/pubmed/24444383
http://dx.doi.org/10.1186/1471-2407-14-32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903446/
https://www.ncbi.nlm.nih.gov/pubmed/24444383
http://dx.doi.org/10.1186/1471-2407-14-32

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