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Targeting the Biophysical Properties of the Myeloma Initiating Cell Niches: A Pharmaceutical Synergism Analysis Using Multi-Scale Agent-Based Modeling

Multiple myeloma, the second most common hematological cancer, is currently incurable due to refractory disease relapse and development of multiple drug resistance. We and others recently established the biophysical model that myeloma initiating (stem) cells (MICs) trigger the stiffening of their ni...

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Detalles Bibliográficos
Autores principales:	Su, Jing, Zhang, Le, Zhang, Wen, Choi, Dong Song, Wen, Jianguo, Jiang, Beini, Chang, Chung-Che, Zhou, Xiaobo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903473/ https://www.ncbi.nlm.nih.gov/pubmed/24475036 http://dx.doi.org/10.1371/journal.pone.0085059

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