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HIV Incidence in a Cohort of Women at Higher Risk in Beira, Mozambique: Prospective Study 2009–2012

BACKGROUND: HIV is prevalent in Sofala Province, Mozambique. To inform future prevention research, we undertook a study in the provincial capital (Beira) to measure HIV incidence in women at higher risk of HIV and assess the feasibility of recruiting and retaining them as research participants. METH...

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Autores principales: Dubé, Karine, Zango, Arlinda, van de Wijgert, Janneke, Meque, Ivete, Ferro, Josefo J., Cumbe, Fidelina, Chen, Pai Lien, Ma, Sabrina, Jolles, Erik, Fumo, Afonso, Robb, Merlin L., Feldblum, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903474/
https://www.ncbi.nlm.nih.gov/pubmed/24475035
http://dx.doi.org/10.1371/journal.pone.0084979
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author Dubé, Karine
Zango, Arlinda
van de Wijgert, Janneke
Meque, Ivete
Ferro, Josefo J.
Cumbe, Fidelina
Chen, Pai Lien
Ma, Sabrina
Jolles, Erik
Fumo, Afonso
Robb, Merlin L.
Feldblum, Paul J.
author_facet Dubé, Karine
Zango, Arlinda
van de Wijgert, Janneke
Meque, Ivete
Ferro, Josefo J.
Cumbe, Fidelina
Chen, Pai Lien
Ma, Sabrina
Jolles, Erik
Fumo, Afonso
Robb, Merlin L.
Feldblum, Paul J.
author_sort Dubé, Karine
collection PubMed
description BACKGROUND: HIV is prevalent in Sofala Province, Mozambique. To inform future prevention research, we undertook a study in the provincial capital (Beira) to measure HIV incidence in women at higher risk of HIV and assess the feasibility of recruiting and retaining them as research participants. METHODS: Women age 18–35 were recruited from schools and places where women typically meet potential sexual partners. Eligibility criteria included HIV-seronegative status and self-report of at least 2 sexual partners in the last month. History of injection drug use was an exclusion criterion, but pregnancy was not. Participants were scheduled for monthly follow-up for 12 months, when they underwent face-to-face interviews, HIV counseling and testing, and pregnancy testing. RESULTS: 387 women were eligible and contributed follow-up data. Most were from 18–24 years old (median 21). Around one-third of participants (33.8%) reported at least one new sexual partner in the last month. Most women (65.5%) reported not using a modern method of contraception at baseline. Twenty-two women seroconverted for a prospective HIV incidence of 6.5 per 100 woman-years (WY; 95% confidence interval (CI): 4.1–9.9). Factors associated with HIV seroconversion in the multivariable analysis were: number of vaginal sex acts without using condoms with partners besides primary partner in the last 7 days (hazard ratio (HR) 1.7; 95% CI: 1.2–2.5) and using a form of contraception at baseline other than hormonal or condoms (vs. no method; HR 25.3; 95% CI: 2.5–253.5). The overall retention rate was 80.0% for the entire follow-up period. CONCLUSIONS: We found a high HIV incidence in a cohort of young women reporting risky sexual behavior in Beira, Mozambique. HIV prevention programs should be strengthened. Regular HIV testing and condom use should be encouraged, particularly among younger women with multiple sexual partners.
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spelling pubmed-39034742014-01-28 HIV Incidence in a Cohort of Women at Higher Risk in Beira, Mozambique: Prospective Study 2009–2012 Dubé, Karine Zango, Arlinda van de Wijgert, Janneke Meque, Ivete Ferro, Josefo J. Cumbe, Fidelina Chen, Pai Lien Ma, Sabrina Jolles, Erik Fumo, Afonso Robb, Merlin L. Feldblum, Paul J. PLoS One Research Article BACKGROUND: HIV is prevalent in Sofala Province, Mozambique. To inform future prevention research, we undertook a study in the provincial capital (Beira) to measure HIV incidence in women at higher risk of HIV and assess the feasibility of recruiting and retaining them as research participants. METHODS: Women age 18–35 were recruited from schools and places where women typically meet potential sexual partners. Eligibility criteria included HIV-seronegative status and self-report of at least 2 sexual partners in the last month. History of injection drug use was an exclusion criterion, but pregnancy was not. Participants were scheduled for monthly follow-up for 12 months, when they underwent face-to-face interviews, HIV counseling and testing, and pregnancy testing. RESULTS: 387 women were eligible and contributed follow-up data. Most were from 18–24 years old (median 21). Around one-third of participants (33.8%) reported at least one new sexual partner in the last month. Most women (65.5%) reported not using a modern method of contraception at baseline. Twenty-two women seroconverted for a prospective HIV incidence of 6.5 per 100 woman-years (WY; 95% confidence interval (CI): 4.1–9.9). Factors associated with HIV seroconversion in the multivariable analysis were: number of vaginal sex acts without using condoms with partners besides primary partner in the last 7 days (hazard ratio (HR) 1.7; 95% CI: 1.2–2.5) and using a form of contraception at baseline other than hormonal or condoms (vs. no method; HR 25.3; 95% CI: 2.5–253.5). The overall retention rate was 80.0% for the entire follow-up period. CONCLUSIONS: We found a high HIV incidence in a cohort of young women reporting risky sexual behavior in Beira, Mozambique. HIV prevention programs should be strengthened. Regular HIV testing and condom use should be encouraged, particularly among younger women with multiple sexual partners. Public Library of Science 2014-01-27 /pmc/articles/PMC3903474/ /pubmed/24475035 http://dx.doi.org/10.1371/journal.pone.0084979 Text en © 2014 Dubé et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dubé, Karine
Zango, Arlinda
van de Wijgert, Janneke
Meque, Ivete
Ferro, Josefo J.
Cumbe, Fidelina
Chen, Pai Lien
Ma, Sabrina
Jolles, Erik
Fumo, Afonso
Robb, Merlin L.
Feldblum, Paul J.
HIV Incidence in a Cohort of Women at Higher Risk in Beira, Mozambique: Prospective Study 2009–2012
title HIV Incidence in a Cohort of Women at Higher Risk in Beira, Mozambique: Prospective Study 2009–2012
title_full HIV Incidence in a Cohort of Women at Higher Risk in Beira, Mozambique: Prospective Study 2009–2012
title_fullStr HIV Incidence in a Cohort of Women at Higher Risk in Beira, Mozambique: Prospective Study 2009–2012
title_full_unstemmed HIV Incidence in a Cohort of Women at Higher Risk in Beira, Mozambique: Prospective Study 2009–2012
title_short HIV Incidence in a Cohort of Women at Higher Risk in Beira, Mozambique: Prospective Study 2009–2012
title_sort hiv incidence in a cohort of women at higher risk in beira, mozambique: prospective study 2009–2012
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903474/
https://www.ncbi.nlm.nih.gov/pubmed/24475035
http://dx.doi.org/10.1371/journal.pone.0084979
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