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Platelet Aggregation Unchanged by Lipoprotein-Associated Phospholipase A(2) Inhibition: Results from an In Vitro Study and Two Randomized Phase I Trials

BACKGROUND: We explored the theorized upregulation of platelet-activating factor (PAF)– mediated biologic responses following lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) inhibition using human platelet aggregation studies in an in vitro experiment and in 2 clinical trials. METHODS AND RESU...

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Detalles Bibliográficos
Autores principales:	Shaddinger, Bonnie C., Xu, Yanmei, Roger, James H., Macphee, Colin H., Handel, Malcolm, Baidoo, Charlotte A., Magee, Mindy, Lepore, John J., Sprecher, Dennis L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903475/ https://www.ncbi.nlm.nih.gov/pubmed/24475026 http://dx.doi.org/10.1371/journal.pone.0083094

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