Inhibitory Potency of 8-Methoxypsoralen on Cytochrome P450 2A6 (CYP2A6) Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21 and CYP2A6*22: Differential Susceptibility Due to Different Sequence Locations of the Mutations

Human cytochrome P450 2A6 (CYP2A6) is a highly polymorphic isoform of CYP2A subfamily. Our previous kinetic study on four CYP2A6 allelic variants (CYP2A6*15, CYP2A6*16, CYP2A6*21 and CYP2A6*22) have unveiled the functional significance of sequence mutations in these variants on coumarin 7-hydroxylat...

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Detalles Bibliográficos
Autores principales: Tiong, Kai Hung, Mohammed Yunus, Nafees Ahemad, Yiap, Beow Chin, Tan, Eng Lai, Ismail, Rusli, Ong, Chin Eng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903516/
https://www.ncbi.nlm.nih.gov/pubmed/24475091
http://dx.doi.org/10.1371/journal.pone.0086230

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