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Linker-Extended Native Cyanovirin-N Facilitates PEGylation and Potently Inhibits HIV-1 by Targeting the Glycan Ligand

Cyanovirin-N (CVN) potently inhibits human immunodeficiency virus type 1 (HIV-1) infection, but both cytotoxicity and immunogenicity have hindered the translation of this protein into a viable therapeutic. A molecular docking analysis suggested that up to 12 residues were involved in the interaction...

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Detalles Bibliográficos
Autores principales:	Chen, Jia, Huang, Dane, Chen, Wei, Guo, Chaowan, Wei, Bo, Wu, Chongchao, Peng, Zhou, Fan, Jun, Hou, Zhibo, Fang, Yongsheng, Wang, Yifei, Kitazato, Kaio, Yu, Guoying, Zou, Chunbin, Qian, Chuiwen, Xiong, Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903522/ https://www.ncbi.nlm.nih.gov/pubmed/24475123 http://dx.doi.org/10.1371/journal.pone.0086455

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