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Prevalence and Evolution of Low Frequency HIV Drug Resistance Mutations Detected by Ultra Deep Sequencing in Patients Experiencing First Line Antiretroviral Therapy Failure

OBJECTIVES: Clinical relevance of low-frequency HIV-1 variants carrying drug resistance associated mutations (DRMs) is still unclear. We aimed to study the prevalence of low-frequency DRMs, detected by Ultra-Deep Sequencing (UDS) before antiretroviral therapy (ART) and at virological failure (VF), i...

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Detalles Bibliográficos
Autores principales:	Vandenhende, Marie-Anne, Bellecave, Pantxika, Recordon-Pinson, Patricia, Reigadas, Sandrine, Bidet, Yannick, Bruyand, Mathias, Bonnet, Fabrice, Lazaro, Estibaliz, Neau, Didier, Fleury, Hervé, Dabis, François, Morlat, Philippe, Masquelier, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903565/ https://www.ncbi.nlm.nih.gov/pubmed/24475178 http://dx.doi.org/10.1371/journal.pone.0086771

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